Figure 119.1
Acute generalized exanthematous pustulosis (AGEP). Histopathology.
Figure 119.5
Drug reaction with eosinophilia and systemic symptoms (DRESS). Histopathology in a case of DRESS: spongiosis is seen in the epidermis, with a superfic...
Figure 119.9
Drug reaction with eosinophilia and systemic symptoms (DRESS). A widespread exfoliative erythema seen in a patient with DRESS following allopurinol gi...
Figure 119.13
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Purpuric macules. The dusky, purpuric lesions on this patient's skin are coalescing and...
Figure 119.17
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Detached epidermis. In SJS/TEN, lesional necrolytic epidermis readily peels back to rev...
Figure 119.21
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Genital involvement. There is confluent erythema of the scrotum and discrete lesions on...
Figure 119.2
Acute generalized exanthematous pustulosis (AGEP). Sheets of sterile non‐follicular pustules on the arm of a patient who developed AGEP 3 days after a...
Figure 119.6
Drug reaction with eosinophilia and systemic symptoms (DRESS). Histopathology in a case of DRESS: this skin biopsy demonstrates features reminiscent o...
Figure 119.10
Drug reaction with eosinophilia and systemic symptoms (DRESS). The erythema multiforme‐like phenotype in DRESS is often accompanied by more severe liv...
Figure 119.14
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Palmoplantar involvement. Multiple circular lesions are present on (a) the palms and (b...
Figure 119.18
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Denuded skin. Extensive epidermal loss in TEN produces large areas of exposed dermis.
Figure 119.3
Acute generalized exanthematous pustulosis (AGEP): similar appearance of pustules at the knee flexure.
Figure 119.7
Drug reaction with eosinophilia and systemic symptoms (DRESS). The most common clinical phenotype is widespread papules and plaques accompanied by cut...
Figure 119.11
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Histopathology. There is parakeratosis overlying the epidermis which has separated from...
Figure 119.15
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Blistering. Lesional skin in SJS/TEN typically blisters forming both vesicles (a), and ...
Figure 119.19
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Ocular involvement. (a) There is eyelid oedema, conjunctivitis and keratitis: the green...
Figure 119.4
Acute generalized exanthematous pustulosis (AGEP). The eruption typically resolves with postpustular desquamation.
Figure 119.8
Drug reaction with eosinophilia and systemic symptoms (DRESS). A morbilliform eruption may occur.
Figure 119.12
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Atypical targets. There are multiple discrete red macules – each has a darker centre an...
Figure 119.16
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Confluent erythema. Individual lesions may coalesce to form large areas of erythema, as...
Figure 119.20
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Lip involvement. Severe cheilitis has produced thick haemorrhagic crusts. This SJS/TEN ...
