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Figure c119/f001
Figure 119.1
 Acute generalized exanthematous pustulosis (AGEP). Histopathology.
Figure c119/f005
Figure 119.5
Drug reaction with eosinophilia and systemic symptoms (DRESS). Histopathology in a case of DRESS: spongiosis is seen in the epidermis, with a superfic...
Figure c119/f009
Figure 119.9
Drug reaction with eosinophilia and systemic symptoms (DRESS). A widespread exfoliative erythema seen in a patient with DRESS following allopurinol gi...
Figure c119/f013
Figure 119.13
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Purpuric macules. The dusky, purpuric lesions on this patient's skin are coalescing and...
Figure c119/f017
Figure 119.17
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Detached epidermis. In SJS/TEN, lesional necrolytic epidermis readily peels back to rev...
Figure c119/f021
Figure 119.21
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Genital involvement. There is confluent erythema of the scrotum and discrete lesions on...
Figure c119/f002
Figure 119.2
Acute generalized exanthematous pustulosis (AGEP). Sheets of sterile non‐follicular pustules on the arm of a patient who developed AGEP 3 days after a...
Figure c119/f006
Figure 119.6
Drug reaction with eosinophilia and systemic symptoms (DRESS). Histopathology in a case of DRESS: this skin biopsy demonstrates features reminiscent o...
Figure c119/f010
Figure 119.10
Drug reaction with eosinophilia and systemic symptoms (DRESS). The erythema multiforme‐like phenotype in DRESS is often accompanied by more severe liv...
Figure c119/f014
Figure 119.14
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Palmoplantar involvement. Multiple circular lesions are present on (a) the palms and (b...
Figure c119/f018
Figure 119.18
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Denuded skin. Extensive epidermal loss in TEN produces large areas of exposed dermis.
Figure c119/f003
Figure 119.3
Acute generalized exanthematous pustulosis (AGEP): similar appearance of pustules at the knee flexure.
Figure c119/f007
Figure 119.7
Drug reaction with eosinophilia and systemic symptoms (DRESS). The most common clinical phenotype is widespread papules and plaques accompanied by cut...
Figure c119/f011
Figure 119.11
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Histopathology. There is parakeratosis overlying the epidermis which has separated from...
Figure c119/f015
Figure 119.15
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Blistering. Lesional skin in SJS/TEN typically blisters forming both vesicles (a), and ...
Figure c119/f019
Figure 119.19
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Ocular involvement. (a) There is eyelid oedema, conjunctivitis and keratitis: the green...
Figure c119/f004
Figure 119.4
Acute generalized exanthematous pustulosis (AGEP). The eruption typically resolves with postpustular desquamation.
Figure c119/f008
Figure 119.8
Drug reaction with eosinophilia and systemic symptoms (DRESS). A morbilliform eruption may occur.
Figure c119/f012
Figure 119.12
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Atypical targets. There are multiple discrete red macules – each has a darker centre an...
Figure c119/f016
Figure 119.16
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Confluent erythema. Individual lesions may coalesce to form large areas of erythema, as...
Figure c119/f020
Figure 119.20
Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). Lip involvement. Severe cheilitis has produced thick haemorrhagic crusts. This SJS/TEN ...