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Figure c136/f001
Figure 136.1
Langerhans cell histiocytosis (LCH) lesion in the skin showing (a) characteristic CD1a‐positive staining of LCH cells and (b) skin LCH cells showing c...
Figure c136/f005
Figure 136.5
Congential self‐healing reticulohistiocytosis (Hashimoto–Pritzker disease) showing ulcerated nodules in an infant.
Figure c136/f009
Figure 136.9
Juvenile xanthogranuloma showing multiple, disseminated, yellow papules.
Figure c136/f013
Figure 136.13
Progressive nodular histiocytosis in a 48‐year‐old man with nodular lesions in the posterior axillary fold. (Courtesy of Professor J. M. Naeyaert, Un...
Figure c136/f017
Figure 136.17
Necrobiotic xanthogranuloma showing a reddish yellow, infiltrative plaque with evidence of necrosis. (Courtesy of Dr S. Walsh, Sunnybrook Hospital, T...
Figure c136/f021
Figure 136.21
Rosai–Dorfman disease showing multiple nodules/tumours with superficial crusting and old scars on the nose.
Figure c136/f002
Figure 136.2
Langerhans cell histiocytosis showing a polymorphic eruption of papules, vesicles, crusts and telangiectasias affecting the nappy area, including the ...
Figure c136/f006
Figure 136.6
Radiograph of a humerus showing a typical punched‐out lytic lesion of bone Langerhans cell histiocytosis.
Figure c136/f010
Figure 136.10
Juvenile xanthogranuloma of the iris. (a) Right eye, 4 November 2001. (b) Right eye, July 2003. (Courtesy of Dr J. Donadieu, Trousseau Hospital, Pari...
Figure c136/f014
Figure 136.14
Xanthoma disseminatum: similar histological picture to juvenile xanthogranuloma consisting of dermal infiltrate of small spindled histiocytes (H&E). ...
Figure c136/f018
Figure 136.18
Reticulohistiocytoma/multicentric reticulohistiocytosis. (a) The dermis contains an infiltrate of large, eosinophilic, cytoplasm‐rich histiocytes with...
Figure c136/f003
Figure 136.3
Langerhans cell histiocytosis showing yellow crusted papules in a seborrhoeic dermatitis distribution in an older child.
Figure c136/f007
Figure 136.7
Haemophagocytosis in haemophagocytic lymphohistiocytosis.
Figure c136/f011
Figure 136.11
Benign cephalic histiocytosis showing multiple, asymptomatic, reddish brown papules on the face of a toddler.
Figure c136/f015
Figure 136.15
(a, b) Xanthoma disseminatum showing large, yellow‐brown plaques affecting the skin folds. (Courtesy of Dr S. Walsh, Sunnybrook Hospital, Toronto, Ca...
Figure c136/f019
Figure 136.19
Multicentric reticulohistiocytosis nodules over the elbows (a) that shrank after an infusion of zoledronic acid (photograph taken 43 days after infusi...
Figure c136/f004
Figure 136.4
Skin‐only Langerhans cell histiocytosis in an infant with spontaneous resolution.
Figure c136/f008
Figure 136.8
Juvenile xanthogranuloma. (a) Small, slightly spindled histiocytes permeate the dermis, splaying collagen fibres. Touton cells are not represented. Ma...
Figure c136/f012
Figure 136.12
Generalized eruptive histiocytosis showing multiple, small, symmetrical, red‐brown papules in an adult. (Courtesy of Dr S. Walsh, Sunnybrook Hospital...
Figure c136/f016
Figure 136.16
Diffuse plane xanthomatosis in a 73‐year‐old man of 7 years’ duration with associated IgG‐κ paraprotein.
Figure c136/f020
Figure 136.20
Rosai–Dorfman disease. (a) The ‘lymph node‐in‐skin’ appearance is highlighted at a low‐power magnification of 20× (H&E). (b) Rosai–Dorfman histiocytes...