Langerhans cell histiocytosis (LCH) lesion in the skin showing (a) characteristic CD1a‐positive staining of LCH cells and (b) skin LCH cells showing c...
Congential self‐healing reticulohistiocytosis (Hashimoto–Pritzker disease) showing ulcerated nodules in an infant.
Juvenile xanthogranuloma showing multiple, disseminated, yellow papules.
Progressive nodular histiocytosis in a 48‐year‐old man with nodular lesions in the posterior axillary fold. (Courtesy of Professor J. M. Naeyaert, Un...
Necrobiotic xanthogranuloma showing a reddish yellow, infiltrative plaque with evidence of necrosis. (Courtesy of Dr S. Walsh, Sunnybrook Hospital, T...
Rosai–Dorfman disease showing multiple nodules/tumours with superficial crusting and old scars on the nose.
Langerhans cell histiocytosis showing a polymorphic eruption of papules, vesicles, crusts and telangiectasias affecting the nappy area, including the ...
Radiograph of a humerus showing a typical punched‐out lytic lesion of bone Langerhans cell histiocytosis.
Juvenile xanthogranuloma of the iris. (a) Right eye, 4 November 2001. (b) Right eye, July 2003. (Courtesy of Dr J. Donadieu, Trousseau Hospital, Pari...
Xanthoma disseminatum: similar histological picture to juvenile xanthogranuloma consisting of dermal infiltrate of small spindled histiocytes (H&E). ...
Reticulohistiocytoma/multicentric reticulohistiocytosis. (a) The dermis contains an infiltrate of large, eosinophilic, cytoplasm‐rich histiocytes with...
Langerhans cell histiocytosis showing yellow crusted papules in a seborrhoeic dermatitis distribution in an older child.
Haemophagocytosis in haemophagocytic lymphohistiocytosis.
Benign cephalic histiocytosis showing multiple, asymptomatic, reddish brown papules on the face of a toddler.
(a, b) Xanthoma disseminatum showing large, yellow‐brown plaques affecting the skin folds. (Courtesy of Dr S. Walsh, Sunnybrook Hospital, Toronto, Ca...
Multicentric reticulohistiocytosis nodules over the elbows (a) that shrank after an infusion of zoledronic acid (photograph taken 43 days after infusi...
Skin‐only Langerhans cell histiocytosis in an infant with spontaneous resolution.
Juvenile xanthogranuloma. (a) Small, slightly spindled histiocytes permeate the dermis, splaying collagen fibres. Touton cells are not represented. Ma...
Generalized eruptive histiocytosis showing multiple, small, symmetrical, red‐brown papules in an adult. (Courtesy of Dr S. Walsh, Sunnybrook Hospital...
Diffuse plane xanthomatosis in a 73‐year‐old man of 7 years’ duration with associated IgG‐κ paraprotein.
Rosai–Dorfman disease. (a) The ‘lymph node‐in‐skin’ appearance is highlighted at a low‐power magnification of 20× (H&E). (b) Rosai–Dorfman histiocytes...