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Figure c140/f001
Figure 140.1
Cell of origin for mature T‐cell leukaemia–lymphomas. AITL, angioimmunoblastic T‐cell lymphoma; ALCL, anaplastic large‐cell lymphoma; CTCL, cutaneous ...
Figure c140/f005
Figure 140.5
Immunopathology of mycosis fungoides/Sézary syndrome (SS).
Figure c140/f009
Figure 140.9
More advanced mycosis fungoides. (a) Typical polycyclic plaques. (b) Plaques involving more than 10% of the body surface.
Figure c140/f013
Figure 140.13
Disease‐specific survival according to (a) clinical stage and (b) T classification. (From Agar et al. 2010 [ ]. With permission from the American Soci...
Figure c140/f017
Figure 140.17
Pagetoid reticulosis showing a striking solitary scaling lesion on the side of the foot of a young man.
Figure c140/f021
Figure 140.21
Sézary syndrome showing (a) erythroderma on the back with (b) palmoplantar hyperkeratoses and prominent nail dystrophy.
Figure c140/f025
Figure 140.25
Dysregulated T‐cell signalling pathways in mycosis fungoides/Sézary syndrome.
Figure c140/f029
Figure 140.29
(a) Low‐power view of CD30+ infiltrate showing a lack of epidermotropism but dense infiltrate in the underlying dermis (b) CD30+ lymphocytic infiltrat...
Figure c140/f033
Figure 140.33
An epidermotropic infiltrate of large pleomorphic lymphoid cells and marked papillary dermal haemorrhage.
Figure c140/f037
Figure 140.37
Marginal zone primary cutaneous B‐cell lymphoma: reactive germinal centres with a non‐epidermotropic monomorphic infiltrate of lymphoplasmacytoid cell...
Figure c140/f041
Figure 140.41
Clinical presentation of primary cutaneous large B‐cell lymphoma on the legs.
Figure c140/f045
Figure 140.45
Extranodal NK/T‐cell lymphoma in the skin: (a) CD56 positivity; (b) rosetting of blood vessels; (c) large atypical mononuclear cells.
Figure c140/f002
Figure 140.2
Histology of mycosis fungoides showing striking epidermotropism with the presence in the epidermis of cytologically atypical, small, dark cells proven...
Figure c140/f006
Figure 140.6
Skin homing properties of epidermotropic T cells in mycosis fungoides (MF) and Sézary syndrome (SS).
Figure c140/f010
Figure 140.10
Nodular mycosis fungoides showing striking nodules on the back of the neck. Similar lesions were present on all four limbs.
Figure c140/f014
Figure 140.14
Overall survival according to prognostic group for mycosis fungoides/Sézary syndrome. (a) Early‐stage group. (b) Late‐stage group [ ].
Figure c140/f018
Figure 140.18
(a) Histology showing a prominent infiltrate of histiocytic cells and lymphoid cells with mild cytological atypia. (b) Giant cells are also present. (...
Figure c140/f022
Figure 140.22
Molecular pathogenesis of mycosis fungoides/Sézary syndrome. NF‐κB, nuclear factor κB; TCR, T‐cell receptor.
Figure c140/f026
Figure 140.26
Suggested management algorithm for bexarotene in cutaneous T‐cell lymphoma. PUVA, psoralen plus ultraviolet A therapy. *Active disease = a slight incr...
Figure c140/f030
Figure 140.30
CD30+ cutaneous lymphoma showing typical ulcerated lesion on the shoulder.
Figure c140/f034
Figure 140.34
Primary cutaneous aggressive epidermotropic CD8+ cutaneous T‐cell lymphoma showing necrotic haemorraghic plaques.
Figure c140/f038
Figure 140.38
Marginal zone primary cutaneous B‐cell lymphoma: typical urticated dermal erythematous papules and plaques predominantly situated on the trunk.
Figure c140/f042
Figure 140.42
Histology of angiocentric B‐cell lymphoma showing B cells within small vascular channels in the dermis. These are stained with membrane markers for B ...
Figure c140/f046
Figure 140.46
Typical clinical presentations of blastic lymphoma in the skin with large mauvish and pigmented dermal plaques involving (a) the trunk and (b) the hea...
Figure c140/f003
Figure 140.3
Electron micrograph of a T cell infiltrating the epidermis in mycosis fungoides, showing the striking cellular contours of the typical cell of Lutzner...
Figure c140/f007
Figure 140.7
Composite photomicrograph showing features of dermatopathic lymphadenopathy. (a) LN1 is characterized by dermatopathic changes with melanin deposition...
Figure c140/f011
Figure 140.11
Clinical variants of mycosis fungoides: (a) annular/polycyclic; (b) poikilodermatous; (c) folliculotropic; (d) hypopigmented.
Figure c140/f015
Figure 140.15
Histology of a lesion in follicular mucinosis showing degeneration of the hair follicle.
Figure c140/f019
Figure 140.19
Granulomatous slack skin showing prominent, lax folds of markedly indurated axillary skin with superficial scaling and wrinkling.
Figure c140/f023
Figure 140.23
Abnormalities of genes controlling cell‐cycle checkpoints in mycosis fungoides/Sézary syndrome (grey, loss of function; red, gain of function).
Figure c140/f027
Figure 140.27
Composite high‐power view of atypical cerebriform cells in type B lymphomatoid papulosis (a) and large ’Reed–Sternberg‐like’ (CD30+) cells in type A h...
Figure c140/f031
Figure 140.31
Low‐power view of subcutaneous infiltrate (a), with high‐power views showing rimming of fat cells by atypical mononuclear cells (b) and medium/large p...
Figure c140/f035
Figure 140.35
Adult T‐cell leukaemia–lymphoma: prominent atypical cells forming a Pautrier microabscess and large pleomorphic cells within the dermis.
Figure c140/f039
Figure 140.39
Primary cutaneous follicle centre cell lymphoma. (a) Extensive erythematous plaque and nodular lesions on the lower back. (b) Typical clinical present...
Figure c140/f043
Figure 140.43
Clinical illustration of the histology illustrated in Figure Note the marbled appearance of the inner thigh, which was woody hard on palpation.
Figure c140/f047
Figure 140.47
Purpuric lesions in an adult patient with myelocytic leukaemia.
Figure c140/f004
Figure 140.4
High‐power view (a) of large‐cell transformation in mycosis fungoides (b).
Figure c140/f008
Figure 140.8
Early mycosis fungoides showing patches in the buttock area.
Figure c140/f012
Figure 140.12
Poikilodermatous mycosis fungoides showing involvement of both breasts.
Figure c140/f016
Figure 140.16
Clinical appearance of follicular mucinosis showing boggy mucin‐secreting plaques on the trunk.
Figure c140/f020
Figure 140.20
High‐power views of Sézary cells in peripheral blood showing (a) a large cell with a very large nucleus and minimal cytoplasm and (b) the ultrastructu...
Figure c140/f024
Figure 140.24
Abnormalities of T‐cell activation‐induced cell death in mycosis fungoides/Sézary syndrome causing defective T‐cell homeostasis (grey, loss of functio...
Figure c140/f028
Figure 140.28
Lymphomatoid papulosis. Note multiple scars on the upper chest area of this patient, with a small number of fresh papular lesions.
Figure c140/f032
Figure 140.32
Subcutaneous panniculitis‐like T‐cell lymphoma: indurated and eroded deep plaque on the thigh.
Figure c140/f036
Figure 140.36
Three clinical presentations of cutaneous adult T‐cell leukaemia–lymphoma: (a) a pruritic papular eruption confined to the auricle, (b) an extensive n...
Figure c140/f040
Figure 140.40
Primary cutaneous large B‐cell lymphoma (a) showing a diffuse pattern of large mononuclear cells (b) and strong Bcl‐2 positivity.
Figure c140/f044
Figure 140.44
Clinical features of lymphomatoid granulomatosis showing extensive purpuric, bruise‐like lesions on the trunk.
Figure c140/f048
Figure 140.48
Specific deposits in a child with leukaemia. Note the two large nodular lesions on the back.