Cell of origin for mature T‐cell leukaemia–lymphomas. AITL, angioimmunoblastic T‐cell lymphoma; ALCL, anaplastic large‐cell lymphoma; CTCL, cutaneous ...
Immunopathology of mycosis fungoides/Sézary syndrome (SS).
More advanced mycosis fungoides. (a) Typical polycyclic plaques. (b) Plaques involving more than 10% of the body surface.
Disease‐specific survival according to (a) clinical stage and (b) T classification. (From Agar et al. 2010 [ ]. With permission from the American Soci...
Pagetoid reticulosis showing a striking solitary scaling lesion on the side of the foot of a young man.
Sézary syndrome showing (a) erythroderma on the back with (b) palmoplantar hyperkeratoses and prominent nail dystrophy.
Dysregulated T‐cell signalling pathways in mycosis fungoides/Sézary syndrome.
(a) Low‐power view of CD30+ infiltrate showing a lack of epidermotropism but dense infiltrate in the underlying dermis (b) CD30+ lymphocytic infiltrat...
An epidermotropic infiltrate of large pleomorphic lymphoid cells and marked papillary dermal haemorrhage.
Marginal zone primary cutaneous B‐cell lymphoma: reactive germinal centres with a non‐epidermotropic monomorphic infiltrate of lymphoplasmacytoid cell...
Clinical presentation of primary cutaneous large B‐cell lymphoma on the legs.
Extranodal NK/T‐cell lymphoma in the skin: (a) CD56 positivity; (b) rosetting of blood vessels; (c) large atypical mononuclear cells.
Histology of mycosis fungoides showing striking epidermotropism with the presence in the epidermis of cytologically atypical, small, dark cells proven...
Skin homing properties of epidermotropic T cells in mycosis fungoides (MF) and Sézary syndrome (SS).
Nodular mycosis fungoides showing striking nodules on the back of the neck. Similar lesions were present on all four limbs.
Overall survival according to prognostic group for mycosis fungoides/Sézary syndrome. (a) Early‐stage group. (b) Late‐stage group [ ].
(a) Histology showing a prominent infiltrate of histiocytic cells and lymphoid cells with mild cytological atypia. (b) Giant cells are also present. (...
Molecular pathogenesis of mycosis fungoides/Sézary syndrome. NF‐κB, nuclear factor κB; TCR, T‐cell receptor.
Suggested management algorithm for bexarotene in cutaneous T‐cell lymphoma. PUVA, psoralen plus ultraviolet A therapy. *Active disease = a slight incr...
CD30+ cutaneous lymphoma showing typical ulcerated lesion on the shoulder.
Primary cutaneous aggressive epidermotropic CD8+ cutaneous T‐cell lymphoma showing necrotic haemorraghic plaques.
Marginal zone primary cutaneous B‐cell lymphoma: typical urticated dermal erythematous papules and plaques predominantly situated on the trunk.
Histology of angiocentric B‐cell lymphoma showing B cells within small vascular channels in the dermis. These are stained with membrane markers for B ...
Typical clinical presentations of blastic lymphoma in the skin with large mauvish and pigmented dermal plaques involving (a) the trunk and (b) the hea...
Electron micrograph of a T cell infiltrating the epidermis in mycosis fungoides, showing the striking cellular contours of the typical cell of Lutzner...
Composite photomicrograph showing features of dermatopathic lymphadenopathy. (a) LN1 is characterized by dermatopathic changes with melanin deposition...
Clinical variants of mycosis fungoides: (a) annular/polycyclic; (b) poikilodermatous; (c) folliculotropic; (d) hypopigmented.
Histology of a lesion in follicular mucinosis showing degeneration of the hair follicle.
Granulomatous slack skin showing prominent, lax folds of markedly indurated axillary skin with superficial scaling and wrinkling.
Abnormalities of genes controlling cell‐cycle checkpoints in mycosis fungoides/Sézary syndrome (grey, loss of function; red, gain of function).
Composite high‐power view of atypical cerebriform cells in type B lymphomatoid papulosis (a) and large ’Reed–Sternberg‐like’ (CD30+) cells in type A h...
Low‐power view of subcutaneous infiltrate (a), with high‐power views showing rimming of fat cells by atypical mononuclear cells (b) and medium/large p...
Adult T‐cell leukaemia–lymphoma: prominent atypical cells forming a Pautrier microabscess and large pleomorphic cells within the dermis.
Primary cutaneous follicle centre cell lymphoma. (a) Extensive erythematous plaque and nodular lesions on the lower back. (b) Typical clinical present...
Clinical illustration of the histology illustrated in Figure Note the marbled appearance of the inner thigh, which was woody hard on palpation.
Purpuric lesions in an adult patient with myelocytic leukaemia.
High‐power view (a) of large‐cell transformation in mycosis fungoides (b).
Early mycosis fungoides showing patches in the buttock area.
Poikilodermatous mycosis fungoides showing involvement of both breasts.
Clinical appearance of follicular mucinosis showing boggy mucin‐secreting plaques on the trunk.
High‐power views of Sézary cells in peripheral blood showing (a) a large cell with a very large nucleus and minimal cytoplasm and (b) the ultrastructu...
Abnormalities of T‐cell activation‐induced cell death in mycosis fungoides/Sézary syndrome causing defective T‐cell homeostasis (grey, loss of functio...
Lymphomatoid papulosis. Note multiple scars on the upper chest area of this patient, with a small number of fresh papular lesions.
Subcutaneous panniculitis‐like T‐cell lymphoma: indurated and eroded deep plaque on the thigh.
Three clinical presentations of cutaneous adult T‐cell leukaemia–lymphoma: (a) a pruritic papular eruption confined to the auricle, (b) an extensive n...
Primary cutaneous large B‐cell lymphoma (a) showing a diffuse pattern of large mononuclear cells (b) and strong Bcl‐2 positivity.
Clinical features of lymphomatoid granulomatosis showing extensive purpuric, bruise‐like lesions on the trunk.
Specific deposits in a child with leukaemia. Note the two large nodular lesions on the back.