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Figure 142.1
Pathological features of actinic keratoses showing alternating parakeratosis and hyperkeratosis.
Figure 142.5
Dermoscopy showing thickened warty appearance of seborrhoeic keratosis.
Figure 142.9
Solitary basal cell carcinoma with pearly edge and minimal hyperkeratosis.
Figure 142.13
Actinic keratosis (AK) management algorithm. *Treatment should be decided following discussion with the patient, assessment of treatment availability ...
Figure 142.17
Cutaneous horn with low height‐to‐base ratio. Pathology showed squamous cell carcinoma at the base.
Figure 142.21
Pathology of Bowen disease showing loss of polarity of the epidermis and the presence of atypical mitoses and giant cells.
Figure 142.25
Superficial basal cell carcinoma mimicking Bowen disease.
Figure 142.29
(a) Large confluent areas of bowenoid papulosis. (b) Following treatment for 6 weeks with 5% imiquimod cream. (c) Marked improvement seen at follow‐up...
Figure 142.33
Key signalling pathways involved in the formation of squamous cell carcinomas (SCCs). Mutations induced by UVB exposure can perturb multiple cellular ...
Figure 142.37
Well‐differentiated squamous cell carcinoma with even circumscribed edge and central crusting.
Figure 142.41
Squamous cell carcinoma (SCC) management algorithm. (Annex 3 reproduced and adapted with permission from the Scottish Intercollegiate Guidelines Netwo...
Figure 142.2
Actinic keratosis.
Figure 142.6
Squamous cell carcinoma showing hyperkeratosis with a raised nodule.
Figure 142.10
‘Low‐risk’ disease characterized by few thin actinic keratoses.
Figure 142.14
(a) Actinic keratoses before treatment with 5% 5‐fluorouracil cream. (b) Three weeks into treatment with daily 5% 5‐fluorouracil cream. (c) Post‐treat...
Figure 142.18
Pathology of post‐ionizing radiation keratosis.
Figure 142.22
Bowen disease.
Figure 142.26
Squamous cell carcinoma with hyperkeratosis and raised thickened edge.
Figure 142.30
Dermoscopy of Bowen disease showing irregular erythematous base, mild hyperkeratosis with vascular structures throughout the lesion.
Figure 142.34
Pathological features of well‐differentiated, early invasive squamous cell carcinoma, showing differentiated keratinocytes invading the underlying der...
Figure 142.38
Seborrhoeic keratosis mimicking squamous cell carcinoma.
Figure 142.42
(a) Pathology of keratoacanthoma showing endophytic growth pattern with epidermal lipping and no evidence of dermal invasion (×20). (Courtesy of Dr M...
Figure 142.3
Lichenoid actinic keratoses.
Figure 142.7
Bowen disease which is usually larger than actinic keratoses with an irregular erythematous base.
Figure 142.11
‘High‐risk’ disease characterized by multiple thick actinic keratoses and previously excised non‐melanoma skin cancer.
Figure 142.15
(a) Hyperkeratotic actinic keratosis before treatment with 5% imiquimod cream. (b) Four weeks into treatment with 5% imiquimod cream. (c) Post‐treatme...
Figure 142.19
Cornoid lamella with parakeratotic column overlying epidermal dyskeratotic and vacuolated cells, representing the clinically visible raised margin see...
Figure 142.23
Multiple areas of Bowen disease on the lower leg.
Figure 142.27
Discoid dermatitis of the lower leg. (Courtesy of Dr W. A. D. Griffiths, Epsom Hospital, Surrey, UK.)
Figure 142.31
Bowen disease management algorithm. *Treatment should be decided following discussion with patient, treatment availability and local expertise with th...
Figure 142.35
Multiple invasive squamous cell carcinomas in a patient with a history of exposure to arsenic.
Figure 142.39
Well‐differentiated squamous cell carcinoma on the helix of the ear (high‐risk site).
Figure 142.43
Scarring seen in a patient with multiple self‐healing squamous epitheliomas.
Figure 142.4
Seborrhoeic keratosis.
Figure 142.8
(a,b) Keratoacanthoma which is often larger and more hyperkeratotic than actinic keratosis.
Figure 142.12
‘High‐risk’ disease characterized by multiple thick actinic keratoses in an immunosuppressed patient on ciclosporin.
Figure 142.16
Typical cutaneous horn. Underlying this lesion, a carcinoma in situ was identified after biopsy.
Figure 142.20
Disseminated superficial actinic porokeratosis on the lower legs.
Figure 142.24
Periungual Bowen disease.
Figure 142.28
(a,b) Plaque with thick scale. Examination elsewhere shows typical scaly plaques seen in psoriasis.
Figure 142.32
(a) Bowen disease before treatment with liquid nitrogen cryotherapy. (b) Dermoscopy prior to treatment, showing crusting with central vascular structu...
Figure 142.36
Raised erythematous invasive squamous cell carcinoma in an elderly patient on a light‐exposed site.
Figure 142.40
Poorly differentiated squamous cell carcinoma presenting as a nodule and lacking typical keratin centre.