‘Porphyrin’ photodynamic therapy uses the haem cycle. ALA, 5‐aminolaevulinic acid; CoA, co‐enzyme A; MAL, methyl aminolevulinate.
Bowen disease on the lower leg (a) before and (b) 1 year after photodynamic therapy (PDT). Stasis change, oedema and xerosis were prominent and althou...
Lesion preparation using a disposable ring curette.
Photodynamic therapy to the lower leg using a red LED source.
Expected residual erythema and crusting 1 week after photodynamic therapy.
Positive patch tests confirming contact allergy to a proprietary preparation of 5‐aminolaevulinic acid (ALA). Contact allergy to both ALA and methyl a...
Crimson red protoporphyrin IX fluorescence in a superficial basal cell carcinoma 3 h after methyl aminolevulinate application, showing the tumour spec...
Superficial basal cell carcinoma on the back (a) before and (b) 1 year after photodynamic therapy. Note the excellent cosmetic outcome, with only the ...
Ambulatory photodynamic therapy. Irradiation is underway, as indicated by the red light emission from the portable inorganic LED source (Ambulight).
Severe phototoxic reaction persisting 1 week after photodynamic therapy in a fair‐skinned subject with marked field change photodamage.
Absorption spectrum of protoporphyrin IX.
Photodynamic therapy (PDT) is ideal for multiple and/or large lesions and field change. This patient had extensive actinic keratosis, Bowen disease an...
Pro‐drug occlusion under Tegaderm. An additional UV/visible light opaque dressing would also be applied if the lesion is on an exposed site.
Daylight photodynamic therapy (PDT) allows field areas of superficial actinic keratosis on exposed sites to be treated in one session. This man had da...
Urticaria at the treatment site immediately after photodynamic therapy.
Field treatment of actinic keratoses on the forehead and temple (a) before and (b) 3 months after a single treatment of topical photodynamic therapy.
Photodynamic therapy (PDT) is ideal for lower leg sites as the risk of poor healing and ulceration is reduced. This patient has lower leg oedema, stas...
Mapping out the irradiation field to include a 5 mm rim of clinically uninvolved skin.
Erythema and oedema immediately after photodynamic therapy.
Dermatitis arising at the photodynamic therapy (PDT) treatment site in a patient who had received multiple treatments with topical PDT to field areas....