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Figure c28/f001
Figure 28.1
Mechanisms of damage in leprosy, and tissues affected. Mechanisms under the broken line are characteristic of disease near the lepromatous end of the ...
Figure c28/f005
Figure 28.5
Erythema nodosum leprosum. Medium‐power view (H&E) showing foamy macrophages with infiltrating polymorphs. There is also a swollen small artery in the...
Figure c28/f009
Figure 28.9
Tuberculoid or borderline tuberculoid leprosy. Back of a Nigerian child showing well‐defined hypopigmented macule with altered skin texture. The lesio...
Figure c28/f013
Figure 28.13
Lepromatous leprosy. (a) Man with nasal collapse and forehead wrinkling. (b) Woman with nasal collapse.
Figure c28/f017
Figure 28.17
Borderline tuberculoid leprosy. Back of Nigerian man showing large well‐defined scaly macules with some marginal elevation. Extensive disease, such as...
Figure c28/f021
Figure 28.21
Type 1 reaction: borderline leprosy in an Ethiopian man. Existing lesions become acutely inflamed, scale and threaten ulceration. Many small new lesio...
Figure c28/f025
Figure 28.25
Necrosis blister in an anaesthetic foot. Necrotic material has tracked to soft skin from the site of trauma, beneath the metatarsal heads.
Figure c28/f002
Figure 28.2
(a) Low‐power view (H&E) showing tuberculoid granulomas around nerve and skin appendages in mid‐dermis and a swollen, deep dermal nerve. There is no e...
Figure c28/f006
Figure 28.6
Indeterminate leprosy. Face of a Nepali child showing vague hypopigmented patch with some central healing. Note the mark of a recent slit‐skin smear.
Figure c28/f010
Figure 28.10
Lepromatous leprosy (borderline lepromatous/lepromatous. Back of a Bangladeshi boy showing numerous, often confluent hypopigmented macules, with relat...
Figure c28/f014
Figure 28.14
Lepromatous leprosy. Examination via a nasal speculum shows a pale septal nodule and bleeding. Such lesions in untreated lepromatous patients constitu...
Figure c28/f018
Figure 28.18
Borderline tuberculoid leprosy. Arm of an Indian woman. A large scaly macule is developing secondary ichthyotic change.
Figure c28/f022
Figure 28.22
Type 2 reaction in lepromatous leprosy in a Nigerian man: erythema nodosum leprosum. Several of the reaction nodules have broken down, releasing pus.
Figure c28/f026
Figure 28.26
Borderline leprosy (BL). Borderline leprosy upgrading to borderline tuberculoid (BT). Buttocks of an Indian man who ‘relapsed’ 3 years after completin...
Figure c28/f003
Figure 28.3
(a) Lepromatous leprosy. Medium‐power view (H&E) showing thin epidermis, a clear subepidermal zone and a dense, uniform macrophage infiltrate in the d...
Figure c28/f007
Figure 28.7
Tuberculoid leprosy. Face of Pakistani woman showing erythematous plaque with a well‐defined active edge, and a small satellite lesion. On the face, s...
Figure c28/f011
Figure 28.11
Lepromatous leprosy. Forearm of an English man showing erythematous macules and infiltration.
Figure c28/f015
Figure 28.15
Lepromatous leprosy. Hands of an Indian man, showing swollen fingers due to leprous dactylitis and one crooked finger due to a pathological fracture. ...
Figure c28/f019
Figure 28.19
Borderline leprosy. Foot of a Bangladeshi child showing enlargement of posterior tibial and anterior tibial nerves.
Figure c28/f023
Figure 28.23
Type 2 reaction in lepromatous leprosy in a Bangladeshi man, showing severe necrosis and ulceration. Erythema nodosum leprosum tends to be more severe...
Figure c28/f004
Figure 28.4
(a) Indeterminate leprosy. Low‐power view (H&E) showing minimal perineurovascular inflammation in the mid‐dermis. (b) High‐power view, Wade–Fite stain...
Figure c28/f008
Figure 28.8
Tuberculoid or borderline tuberculoid leprosy. Upper arm of Indian man, showing typical dry, hairless, hypopigmented plaque with scaly, erythematous e...
Figure c28/f012
Figure 28.12
Lepromatous leprosy. Face of a man showing diffuse infiltration of the skin and appearance of nodules on the nose and lip.
Figure c28/f016
Figure 28.16
Borderline leprosy. Knee of Saudi‐Arabian woman, showing classical annular lesions with well‐defined centres. Slit‐skin smears show acid‐fast bacilli....
Figure c28/f020
Figure 28.20
Borderline leprosy (BL). Borderline tuberculoid (BT) downgrading to BL. Back of a Nigerian woman, showing typical well‐defined hypopigmented macules o...
Figure c28/f024
Figure 28.24
Lucio phenomenon in a Mexican man. The severe recurrent ulceration due to deep subcutaneous vasculitis may be fatal. (Courtesy of Dr J. Keystone, the...