Diagnoses of infectious syphilis made at GUM clinics in England, Scotland and Wales peaked towards the end of World War II, and then fell sharply in t...
Primary and secondary syphilis by sex and sexual behaviour in selected areas of the USA, 2007–2011. MSM, men who have sex with men; MSW, men who have ...
Treponema pallidum showing typical morphology.
(a) Bilateral early chancres of the labia majora. (b) Chancre of the fourchette with surrounding oedema. This patient also had accompanying gonorrhoea...
Syphilitic leukoderma showing depigmentation at sites of healed secondary lesions on the neck and upper back.
Oral lesions of secondary syphilis. (a) Split papules at the angle of the mouth. (b) Mucous patches on the buccal mucosa.
Mucosal lesions of tertiary syphilis. (a) Early gumma of the hard palate. (b) Perforated gumma of the hard palate.
Neurosyphilis causing Argyll–Robertson pupils of the eyes. The abdomen shows multiple scars after surgical intervention for tabetic crises mimicking a...
(a) Early congenital syphilis showing serous nasal discharge from nasopharyngitis – ‘syphilitic snuffles’. (b) Congenital syphilitic facies with saddl...
Widespread syphilitic osteitis, periostitis and destructive metaphysitits of the long bones.
Clutton's joints in late congenital syphilis.
Diagnoses of infectious syphilis by gender in England, 2003–2012. (Data from GUMCAD Public Health England, http://www.hpa.org.uk/gumcad . © Crown co...
Secondary syphilis showing psoriasiform hyperplasia of the epidermis with spongiosis and interface change with abundant plasma cells.
Immunofluorescent image of Treponemal pallidum .
(a) Primary chancre of the upper lip showing a typical button‐like induration. (b) Primary chancre of the left tonsil.
Secondary syphilis showing papular syphilides on (a) the forearms and (b) the trunk.
(a) Papular lesions of the face extending into the hairline. (b) Moth‐eaten alopecia in secondary syphilis associated with papular lesions of the scal...
Visceral lesions of tertiary syphilis. (a) Gumma of the liver causing portal vein obstruction. (b) Portal hypertension with caput medusa caused by hep...
Tabes dorsalis. (a) Charcot's (neuropathic) joints of the knee. (b) X‐ray of Charcot's joints of the knee showing a loss of normal alignment with mult...
Early congenital syphilis with widespread papular and vesicular lesions covering the body.
Dactylitis of the little finger in late congenital syphilis.
Early congenital syphilis showing osteitis of the skull bones (arrow) causing a worm‐eaten appearance.
Diagnoses of infectious syphilis by age and gender in England, 2012. (Data from GUMCAD Public Health England, http://www.hpa.org.uk/gumcad . © Crown...
Secondary syphilis. Immunohistochemistry shows numerous spirochaetes within the epidermis.
Penile chancres. (a) Primary syphilis showing chancres on the glans and shaft of the penis. (b) Taking specimens for dark ground microscopy from a pen...
Syphilitic paronychia caused by a primary chancre of the middle finger.
Secondary syphilis showing psoriasiform lesions of the palms.
Syphilitic iritis causing circumcorneal injection of the blood vessels.
Chronic interstitial glossitis with bilateral squamous carcinoma.
Typical serological responses at different stages and in response to treatment of syphilis. FTA, fluorescent treponemal antibody; Ig, immunoglobulin; ...
Early congenital syphilis with ruptured bullous pemiphigioid lesions on the soles of the feet.
Late congenital syphilis with gummata on the forehead and scalp.
Malformations of the secondary dentition in late congenital syphilis. (a) Hutchinson's teeth. (b) Close‐up of Hutchinson's incisors.
Reported cases of syphilis by stage of infection in the USA, 1941–2011. (Courtesy of Centers for Disease Control and Prevention, Atlanta, GA, USA.)
Treponema pallidum on dark ground microscopy.
Anal lesion in syphilis.
Secondary syphilis. (a) Extensive truncal maculopapular rash. (b) Macular rash with lesions following the skin lines of cleavage. (c) Papulosquamous p...
Condylomata lata of secondary syphilis: (a, b) perianal; (c) round the groin; (d) perivulval; (e) on the penile shaft with surrounding depigmentation ...
Skin lesions in tertiary syphilis. (a) Nodular gummata of the arm. (b) Psoriasiform gummata on the neck. (c) Psoriasiform gummata of the leg before (r...
Cardiovascular syphilis. (a) Chest X‐ray showing a dilated aorta with linear calcification in the wall of the ascending aorta. (b) Chest X‐ray showing...
Reported cases of congenital syphilis (CS) among infants by year of birth and rates of primary and secondary syphilis (P&S) among women in the USA, 20...
Wimberger's sign (arrow) – destruction of the proximal metaphyses of the tibiae.
Early congenital syphilis with chorioretinitis and optic atrophy.
Moon's molars showing a dome‐shaped malformation and loss of cusps (arrows).