Instruments for skin biopsy, including scalpel, scissors, needle holder and skin hooks.
(a) Connective tissue naevus. The section stained with H&E only shows focal condensation of the collagen. (b) An elastic van Gieson stain shows marked...
Chloroacetate esterase stain. Mast cells appear red with this technique.
Direct immunofluorescence of lupus erythematosus showing speckled basement membrane zone deposition of IgM (green) and ethidium bromide counterstain (...
(a) Typical example of a Merkel cell carcinoma consisting of hyperchromatic cells with scanty cytoplasm. (b) Immunostaining with cytokeratin 20 highli...
(a) Subacute spongiotic process (eczema) with hyperplasia of Langerhans cells presenting in a large nest within the epidermis mimicking a Pautrier mic...
Bizarre multinucleated giant cells from a Spitz naevus.
Lichenoid tissue reaction. Various histopathological consequences follow damage to the dermal–epidermal junction. These histopathological changes are ...
Disposable punch for cutaneous biopsy.
Periodic acid–Schiff stain showing numerous hyphae within the hair shaft in an endothrix infection.
Different immunofluorescence techniques: (a) direct, (b) indirect and (c) double staining.
Direct immunofluorescence of pemphigus showing deposition of intercellular IgG in the epidermis.
(a) Extramammary Paget disease showing prominent colonization of the epidermis by numerous, atypical, rounded cells with pink cytoplasm. (b) Tumour ce...
(a) Sheets of large, atypical lymphoid cells with pleomorphic nuclei and pink cytoplasm. (b) Positive staining of atypical cells in a case of CD30‐pos...
Biopsy from a case of Darier disease showing the histological features of parakeratosis, dyskeratosis and acantholysis and the formation of villi.
Blocking of elliptical skin biopsy specimens. (a) Neoplastic lesions. Multiple transverse blocks through the whole lesion allow for histopathological ...
Periodic acid–Schiff stain showing thickening of the basement membrane zone in cutaneous lupus erythematosus.
Different immunoperoxidase techniques: (a) direct, (b) indirect, (c) modified indirect and (d) with peroxidase–antiperoxidase (PAP) complex.
Direct immunofluorescence of bullous pemphigoid showing linear basement membrane zone deposition of IgG (green) and ethidium bromide counterstain (ora...
(a) Glomus tumour composed of uniform, round cells with pale cytoplasm and well‐defined cytoplasmic membrane. (b) Strong cytoplasmic staining for smoo...
An H&E‐stained smear from a lesion of herpes simplex showing multinucleate giant cells and degenerative nuclear changes.
Prominent liquefaction degeneration from a case of lichen sclerosus.
Photocopy procedure for recording the preparation of blocks. (a) The appearance of a macroscopic specimen of melanoma. (b) Transverse blocks are taken...
(a) A prominent lymphocytic infiltrate which is focally lichenoid and is associated with extravasation of red blood cells in a case of lichen aureus (...
Avidin–biotin staining methods. (a) Antibody coupled with biotin binds with the antigen in the tissue. Avidin coupled with peroxidase binds to the bio...
(a) Poorly differentiated tumour composed of pleomorphic spindle‐shaped cells in the dermis (H&E). (b) Diffuse positivity of tumour cells for the pan‐...
(a) Typical dermatofibrosarcoma protuberans composed of monotonous, spindle‐shaped cells with hyperchromatic nuclei arranged in a prominent storiform ...
Extensive dermal pigmentation as a result of the application of Monsel's solution.
Epidermolytic hyperkeratosis seen in a biopsy from a patient with congenital bullous ichthyosiform erythroderma.