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Figure c03/f001
Figure 03.1
Instruments for skin biopsy, including scalpel, scissors, needle holder and skin hooks.
Figure c03/f005
Figure 03.5
(a) Connective tissue naevus. The section stained with H&E only shows focal condensation of the collagen. (b) An elastic van Gieson stain shows marked...
Figure c03/f009
Figure 03.9
Chloroacetate esterase stain. Mast cells appear red with this technique.
Figure c03/f013
Figure 03.13
Direct immunofluorescence of lupus erythematosus showing speckled basement membrane zone deposition of IgM (green) and ethidium bromide counterstain (...
Figure c03/f017
Figure 03.17
(a) Typical example of a Merkel cell carcinoma consisting of hyperchromatic cells with scanty cytoplasm. (b) Immunostaining with cytokeratin 20 highli...
Figure c03/f021
Figure 03.21
(a) Subacute spongiotic process (eczema) with hyperplasia of Langerhans cells presenting in a large nest within the epidermis mimicking a Pautrier mic...
Figure c03/f025
Figure 03.25
Bizarre multinucleated giant cells from a Spitz naevus.
Figure c03/f029
Figure 03.29
Lichenoid tissue reaction. Various histopathological consequences follow damage to the dermal–epidermal junction. These histopathological changes are ...
Figure c03/f002
Figure 03.2
Disposable punch for cutaneous biopsy.
Figure c03/f006
Figure 03.6
Periodic acid–Schiff stain showing numerous hyphae within the hair shaft in an endothrix infection.
Figure c03/f010
Figure 03.10
Different immunofluorescence techniques: (a) direct, (b) indirect and (c) double staining.
Figure c03/f014
Figure 03.14
Direct immunofluorescence of pemphigus showing deposition of intercellular IgG in the epidermis.
Figure c03/f018
Figure 03.18
(a) Extramammary Paget disease showing prominent colonization of the epidermis by numerous, atypical, rounded cells with pink cytoplasm. (b) Tumour ce...
Figure c03/f022
Figure 03.22
(a) Sheets of large, atypical lymphoid cells with pleomorphic nuclei and pink cytoplasm. (b) Positive staining of atypical cells in a case of CD30‐pos...
Figure c03/f026
Figure 03.26
Biopsy from a case of Darier disease showing the histological features of parakeratosis, dyskeratosis and acantholysis and the formation of villi.
Figure c03/f003
Figure 03.3
Blocking of elliptical skin biopsy specimens. (a) Neoplastic lesions. Multiple transverse blocks through the whole lesion allow for histopathological ...
Figure c03/f007
Figure 03.7
Periodic acid–Schiff stain showing thickening of the basement membrane zone in cutaneous lupus erythematosus.
Figure c03/f011
Figure 03.11
Different immunoperoxidase techniques: (a) direct, (b) indirect, (c) modified indirect and (d) with peroxidase–antiperoxidase (PAP) complex.
Figure c03/f015
Figure 03.15
Direct immunofluorescence of bullous pemphigoid showing linear basement membrane zone deposition of IgG (green) and ethidium bromide counterstain (ora...
Figure c03/f019
Figure 03.19
(a) Glomus tumour composed of uniform, round cells with pale cytoplasm and well‐defined cytoplasmic membrane. (b) Strong cytoplasmic staining for smoo...
Figure c03/f023
Figure 03.23
An H&E‐stained smear from a lesion of herpes simplex showing multinucleate giant cells and degenerative nuclear changes.
Figure c03/f027
Figure 03.27
Prominent liquefaction degeneration from a case of lichen sclerosus.
Figure c03/f004
Figure 03.4
Photocopy procedure for recording the preparation of blocks. (a) The appearance of a macroscopic specimen of melanoma. (b) Transverse blocks are taken...
Figure c03/f008
Figure 03.8
(a) A prominent lymphocytic infiltrate which is focally lichenoid and is associated with extravasation of red blood cells in a case of lichen aureus (...
Figure c03/f012
Figure 03.12
Avidin–biotin staining methods. (a) Antibody coupled with biotin binds with the antigen in the tissue. Avidin coupled with peroxidase binds to the bio...
Figure c03/f016
Figure 03.16
(a) Poorly differentiated tumour composed of pleomorphic spindle‐shaped cells in the dermis (H&E). (b) Diffuse positivity of tumour cells for the pan‐...
Figure c03/f020
Figure 03.20
(a) Typical dermatofibrosarcoma protuberans composed of monotonous, spindle‐shaped cells with hyperchromatic nuclei arranged in a prominent storiform ...
Figure c03/f024
Figure 03.24
Extensive dermal pigmentation as a result of the application of Monsel's solution.
Figure c03/f028
Figure 03.28
Epidermolytic hyperkeratosis seen in a biopsy from a patient with congenital bullous ichthyosiform erythroderma.