The haem molecule and its key structural features. The alternation of single and double bonds around the tetrapyrrole ring indicates the aromaticity o...
Typical subepidermal bulla in a bullous porphyria: (a) clinical appearance, and (b) histological appearance.
Porphyria cutanea tarda: erosions, blisters, pigmentary changes and scarring.
The pathway of haem biosynthesis showing the six key structural changes.
High‐performance liquid chromatography (HPLC) analysis: the more carboxylate groups it possesses, the faster a porphyrin molecule passes through the c...
Oedema during an acute painful attack in a child with erythropoietic protoporphyria.
The pathway of haem biosynthesis showing the enzyme deficiency associated with each porphyria. Abbreviations of the disease names are defined in the t...
Congenital erythropoietic porphyria: scarring of skin with resorption of terminal phalanges. (Courtesy of Dr A. du Vivier, King's College Hospital, L...
Typical scars on the cheeks in erythropoietic protoporphyria.
The pathogenesis of skin disease in porphyria.
Porphyria cutanea tarda is caused by production of an inhibitor of uroporphyrinogen decarboxylase (UROD) in the liver, in the presence of iron. (Adap...
Liver biopsy in protoporphyric liver disease showing nodules of cirrhosis and black staining by deposits of protoporphyrin.