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Figure c65/f001
Figure 65.1
Ichthyosis vulgaris. (a) Fine scaling and (b) accentuated palmar creases. Courtesy of (a) Dr M. Judge, Salford Royal NHS Trust, UK ; (b) the Departme...
Figure c65/f005
Figure 65.5
Autosomal recessive congenital ichthyosis. Sheddding of collodion membranes after 1 week.
Figure c65/f009
Figure 65.9
(a,b) Clinical phenotype of ALOXE3 mutations. Note palmoplantar hyperlinearity resembling accentuated creases in ichthyosis vulgaris (in b). (Court...
Figure c65/f013
Figure 65.13
Histological diagnosis of epidermolytic hyperkeratosis.
Figure c65/f017
Figure 65.17
Moulting (‘Mauserung’) phenomenon in superficial epidermolytic ichthyosis. (Courtesy of the Department of Dermatology, University Hospital Münster, M...
Figure c65/f021
Figure 65.21
Symmetrical progressive erythrokeratoderma. (Courtesy of Dr A. G. Smith, North Staffordshire Hospital, Stoke‐on‐Trent, UK.)
Figure c65/f025
Figure 65.25
Congenital hemidysplasia–ichthyosiform naevus–limb defect (CHILD) naevus with yellowish keratosis and ipsilateral limb defect. (Courtesy of the Depar...
Figure c65/f029
Figure 65.29
Keratolysis exfoliativa of the palms.
Figure c65/f033
Figure 65.33
Trichothiodystrophy. Lamellar scaling similar to bathing suit ichthyosis.
Figure c65/f037
Figure 65.37
Acquired ichthyosis in an adult Asian man with multisystem sarcoidosis. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure c65/f041
Figure 65.41
Pachyonychia congenita: (a) focal keratoderma on mechanically stressed areas; and (b) typical wedge‐shaped nail.
Figure c65/f045
Figure 65.45
Loricrin keratoderma.
Figure c65/f049
Figure 65.49
Marginal papular keratoderma (acrokeratoelastoidosis, punctate palmoplantar keratoderma type 3 (PPKP3)): crateriform punctate keratosis at the margin ...
Figure c65/f053
Figure 65.53
Vohwinkel syndrome: (a) ‘starfish’ lesions; and (b) pseudo‐ainhum.
Figure c65/f057
Figure 65.57
Papillon–Lefèvre syndrome: (a) Loss of dentition. (b) Diffuse plantar hyperkeratosis. (c) Psoriasiform palmar phenotype.
Figure c65/f061
Figure 65.61
Keratoderma associated with lupus erythematosus. (Courtesy of Dr I. Sarkany, Royal Free Hospital, London, UK.)
Figure c65/f065
Figure 65.65
Porokeratosis of Mibelli.
Figure c65/f069
Figure 65.69
Circumscribed hypokeratosis on the inner part of the forefoot of a female patient. (Courtesy of Dr F. Schedel, Department of Dermatology, University ...
Figure c65/f002
Figure 65.2
Recessive X‐linked ichthyosis. (a) Scaling on the arm, (b) on the legs, (c) on the trunk and (d) patient with light grey scaling. Courtesy of (a)–(c)...
Figure c65/f006
Figure 65.6
Bathing suit ichthyosis. Lamellar scaling on areas with high skin temperature. (Courtesy of the Department of Dermatology, University Hospital Münste...
Figure c65/f010
Figure 65.10
Clinical phenotype of NIPAL4 mutations. (a,b) Diffuse yellowish keratoderma on palms and soles. (c) Reticulate scaling on the trunk. (Courtesy of t...
Figure c65/f014
Figure 65.14
Special genetic aspect in keratinopathic ichthyosis. (a) Epidermolytic naevus in a father of an affected boy with generalized epidermolytic ichthyosis...
Figure c65/f018
Figure 65.18
Congenital reticular ichthyosiform erythroderma. Note pale confetti‐like spots representing localized spontaneous healing. (Courtesy of the Departmen...
Figure c65/f022
Figure 65.22
Keratosis linearis–ichthyosis congenita–sclerosing keratoderma (KLICK). Note the linear distribution of the keratotic papules.
Figure c65/f026
Figure 65.26
Ichthyosis follicularis–alopecia–photophobia (IFAP) syndrome. (Courtesy of Dr A. S. Paller, Department of Dermatology and Pediatrics, Chicago, USA.)
Figure c65/f030
Figure 65.30
Sjögren–Larsson syndrome. A 3‐year‐old girl with spastic diplegia. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure c65/f034
Figure 65.34
Ichthyosis prematurity syndrome. (a) Neonatal presentation. (b) Same patient after 3 months. Note mild velvet‐like skin texture. (Courtesy of the Dep...
Figure c65/f038
Figure 65.38
Pityriasis rotunda. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure c65/f042
Figure 65.42
(a) Non‐epidermolytic palmoplantar keratoderma suggestive of AQP5 . (b) Palm of a 38‐year‐old man, who reported on extreme skin sensitivity to water ...
Figure c65/f046
Figure 65.46
Striate and focal palmoplantar keratoderma. (a) Hands and (b) feet belong to the same patient. (Courtesy of the Department of Dermatology, University...
Figure c65/f050
Figure 65.50
Cole disease. (a) Forearm with hypopigmentation and (b) mild keratoderma in the same patient. (Courtesy of Dr Y. Gilaberte, Hospital San Jorge, Huesc...
Figure c65/f054
Figure 65.54
Mitochondrial keratoderma with deafness.
Figure c65/f058
Figure 65.58
Olmsted syndrome: (a) gross keratoderma with striate features, and (b) periorificial hyperkeratosis. (Courtesy of Professor R. K. Winkelmann, Mayo Cl...
Figure c65/f062
Figure 65.62
Norwegian scabies manifesting with keratoderma. (Courtesy of Dr. N. Walker, Oxford Radcliffe Hospital, Oxford, UK.)
Figure c65/f066
Figure 65.66
Kyrle disease/acquired perforating dermatosis: large keratinous plugs on the thigh.
Figure c65/f003
Figure 65.3
Harlequin ichthyosis. (a) Neonate, (b) aged 6 weeks on retinoid therapy and (c) 6 months. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure c65/f007
Figure 65.7
Autosomal recessive congenital ichthyosis. (a) Congenital ichthyosiform erythroderma. (b) Lamellar ichthyosis. (Courtesy of the Department of Dermato...
Figure c65/f011
Figure 65.11
  Clinical phenotype of CERS3 deficiency. Mild plantar keratoderma with hyperlinearity. (Courtesy of the Department of Dermatology, University Hospit...
Figure c65/f015
Figure 65.15
Epidermolytic ichthyosis without mosaicism. (a) Arms, (b) legs, (c) palms indicative of KRT1 and (d) palms indicative of KRT10 mutations. (a)–(c) ...
Figure c65/f019
Figure 65.19
Ichthyosis.Hystrix with striate lesions on the hand. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure c65/f023
Figure 65.23
Exfoliative ichthyosis with pronounced plantar keratoderma. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, Germany...
Figure c65/f027
Figure 65.27
Comèl–Netherton syndrome. (a) Trichorrexis invaginata. (b) Congenital ichthyosiform erythroderma with failure to thrive. (c) Ichthyosis linearis circu...
Figure c65/f031
Figure 65.31
Keratitis–ichthyosis–deafness syndrome. Adult with squamous cell carcinoma on the arm. (Courtesy of Dr D. J. Atherton, Great Ormond Street Hospital f...
Figure c65/f035
Figure 65.35
Diagnostic management and clinical monitoring in ichthyosis. ENT, ear, nose and throat; GC‐MS, gas chromatography–mass spectrometry; IgE, immunoglobul...
Figure c65/f039
Figure 65.39
Epidermolytic palmoplantar keratoderma caused by a mutation in KRT9 encoding keratin 9.
Figure c65/f043
Figure 65.43
Mal de Meleda. Plantar phenotype without superinfection. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, Germany.)
Figure c65/f047
Figure 65.47
Punctate palmoplantar keratoderma. Small even keratotic papules on the palms (a) and confluent hyperkeratosis on the feet of the same patient (b). (C...
Figure c65/f051
Figure 65.51
Transient aquagenic keratoderma showing whitish maceration of the palmar skin following immersion. (Courtesy of Dr G. Kavanagh, Royal Infirmary of Ed...
Figure c65/f055
Figure 65.55
Huriez syndrome: (a) keratoderma, and (b) atrophic skin over the dorsa of the hand and sclerodactyly. (Courtesy of Dr M. van Steensel, Department of ...
Figure c65/f059
Figure 65.59
Oculocutaneous tyrosinaemia (Richner–Hanhart syndrome) with callosity‐like hyperkeratoses.
Figure c65/f063
Figure 65.63
Oudtshoorn disease: (a) palmar lesions, and (b) truncal lesions.
Figure c65/f067
Figure 65.67
Digitate hyperkeratosis. (Courtesy of Dr F. A. Ive, Dryburn Hospital, Durham, UK.)
Figure c65/f004
Figure 65.4
Ultrastructural diagnosis of harlequin ichthyosis. (a) Abnormal lamellar bodies in ABCA12 deficiency. (b) Morphology of normal lamellar bodies in gran...
Figure c65/f008
Figure 65.8
Self‐improving congenital ichthyosis. (a) Collodion baby at birth. (b) Mild ichthyosis and minimal erythroderma at the age of 21 months. (Courtesy of...
Figure c65/f012
Figure 65.12
Ultrastructure of transglutaminase‐1 deficient skin with typical cholesterol clefts in the stratum corneum. (Courtesy of Dr I. Hausser, Heidelberg, G...
Figure c65/f016
Figure 65.16
Superficial epidermolytic ichthyosis. Involvement around the navel. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster,...
Figure c65/f020
Figure 65.20
Erythrokeratoderma variabilis. Migrating polycyclic erythematous lesions.
Figure c65/f024
Figure 65.24
Conradi–Hünermann–Happle syndrome. (Courtesy of Dr D. J. Atherton, London, UK.)
Figure c65/f028
Figure 65.28
Inflammatory peeling skin disease (peeling skin syndrome type B). (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, G...
Figure c65/f032
Figure 65.32
Neutral lipid storage disease with ichthyosis. (a) Lipid vacuoles (Jordan anomaly). (b) Ichthyosiform erythroderma. Courtesy of Dr M. Judge, Salford ...
Figure c65/f036
Figure 65.36
Acquired ichthyosis in a man with cutaneous T‐cell lymphoma.
Figure c65/f040
Figure 65.40
‘Voerner–Unna–Thost’ keratoderma: even yellow hyperkeratosis of the sole with red border.
Figure c65/f044
Figure 65.44
Mal de Meleda. Trichophyton rubrum superinfection of the left hand. (Courtesy of the Department of Dermatology, University Hospital Münster, Münste...
Figure c65/f048
Figure 65.48
Spiny keratoderma. Present since the age of 20 on the palms and soles. Son and daughter also affected.
Figure c65/f052
Figure 65.52
Aquagenic palmar wrinkling in cystic fibrosis.
Figure c65/f056
Figure 65.56
Tylosis with oesophageal cancer (Howel‐Evans syndrome). (a) Keratoderma and (b) oral mucosal lesions. (Courtesy of Professor W. R. Tyldesley, Liverpo...
Figure c65/f060
Figure 65.60
Keratoderma climactericum.
Figure c65/f064
Figure 65.64
Disseminated superficial actinic porokeratoses: annular keratotic lesions with a raised margin.
Figure c65/f068
Figure 65.68
Flegel disease: polygonal keratotic lesions on the legs.