Figure 65.1
Ichthyosis vulgaris. (a) Fine scaling and (b) accentuated palmar creases. Courtesy of (a) Dr M. Judge, Salford Royal NHS Trust, UK ; (b) the Departme...
Figure 65.5
Autosomal recessive congenital ichthyosis. Sheddding of collodion membranes after 1 week.
Figure 65.9
(a,b) Clinical phenotype of ALOXE3 mutations. Note palmoplantar hyperlinearity resembling accentuated creases in ichthyosis vulgaris (in b). (Court...
Figure 65.13
Histological diagnosis of epidermolytic hyperkeratosis.
Figure 65.17
Moulting (‘Mauserung’) phenomenon in superficial epidermolytic ichthyosis. (Courtesy of the Department of Dermatology, University Hospital Münster, M...
Figure 65.21
Symmetrical progressive erythrokeratoderma. (Courtesy of Dr A. G. Smith, North Staffordshire Hospital, Stoke‐on‐Trent, UK.)
Figure 65.25
Congenital hemidysplasia–ichthyosiform naevus–limb defect (CHILD) naevus with yellowish keratosis and ipsilateral limb defect. (Courtesy of the Depar...
Figure 65.29
Keratolysis exfoliativa of the palms.
Figure 65.33
Trichothiodystrophy. Lamellar scaling similar to bathing suit ichthyosis.
Figure 65.37
Acquired ichthyosis in an adult Asian man with multisystem sarcoidosis. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure 65.41
Pachyonychia congenita: (a) focal keratoderma on mechanically stressed areas; and (b) typical wedge‐shaped nail.
Figure 65.45
Loricrin keratoderma.
Figure 65.49
Marginal papular keratoderma (acrokeratoelastoidosis, punctate palmoplantar keratoderma type 3 (PPKP3)): crateriform punctate keratosis at the margin ...
Figure 65.53
Vohwinkel syndrome: (a) ‘starfish’ lesions; and (b) pseudo‐ainhum.
Figure 65.57
Papillon–Lefèvre syndrome: (a) Loss of dentition. (b) Diffuse plantar hyperkeratosis. (c) Psoriasiform palmar phenotype.
Figure 65.61
Keratoderma associated with lupus erythematosus. (Courtesy of Dr I. Sarkany, Royal Free Hospital, London, UK.)
Figure 65.65
Porokeratosis of Mibelli.
Figure 65.69
Circumscribed hypokeratosis on the inner part of the forefoot of a female patient. (Courtesy of Dr F. Schedel, Department of Dermatology, University ...
Figure 65.2
Recessive X‐linked ichthyosis. (a) Scaling on the arm, (b) on the legs, (c) on the trunk and (d) patient with light grey scaling. Courtesy of (a)–(c)...
Figure 65.6
Bathing suit ichthyosis. Lamellar scaling on areas with high skin temperature. (Courtesy of the Department of Dermatology, University Hospital Münste...
Figure 65.10
Clinical phenotype of NIPAL4 mutations. (a,b) Diffuse yellowish keratoderma on palms and soles. (c) Reticulate scaling on the trunk. (Courtesy of t...
Figure 65.14
Special genetic aspect in keratinopathic ichthyosis. (a) Epidermolytic naevus in a father of an affected boy with generalized epidermolytic ichthyosis...
Figure 65.18
Congenital reticular ichthyosiform erythroderma. Note pale confetti‐like spots representing localized spontaneous healing. (Courtesy of the Departmen...
Figure 65.22
Keratosis linearis–ichthyosis congenita–sclerosing keratoderma (KLICK). Note the linear distribution of the keratotic papules.
Figure 65.26
Ichthyosis follicularis–alopecia–photophobia (IFAP) syndrome. (Courtesy of Dr A. S. Paller, Department of Dermatology and Pediatrics, Chicago, USA.)
Figure 65.30
Sjögren–Larsson syndrome. A 3‐year‐old girl with spastic diplegia. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure 65.34
Ichthyosis prematurity syndrome. (a) Neonatal presentation. (b) Same patient after 3 months. Note mild velvet‐like skin texture. (Courtesy of the Dep...
Figure 65.38
Pityriasis rotunda. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure 65.42
(a) Non‐epidermolytic palmoplantar keratoderma suggestive of AQP5 . (b) Palm of a 38‐year‐old man, who reported on extreme skin sensitivity to water ...
Figure 65.46
Striate and focal palmoplantar keratoderma. (a) Hands and (b) feet belong to the same patient. (Courtesy of the Department of Dermatology, University...
Figure 65.50
Cole disease. (a) Forearm with hypopigmentation and (b) mild keratoderma in the same patient. (Courtesy of Dr Y. Gilaberte, Hospital San Jorge, Huesc...
Figure 65.54
Mitochondrial keratoderma with deafness.
Figure 65.58
Olmsted syndrome: (a) gross keratoderma with striate features, and (b) periorificial hyperkeratosis. (Courtesy of Professor R. K. Winkelmann, Mayo Cl...
Figure 65.62
Norwegian scabies manifesting with keratoderma. (Courtesy of Dr. N. Walker, Oxford Radcliffe Hospital, Oxford, UK.)
Figure 65.66
Kyrle disease/acquired perforating dermatosis: large keratinous plugs on the thigh.
Figure 65.3
Harlequin ichthyosis. (a) Neonate, (b) aged 6 weeks on retinoid therapy and (c) 6 months. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure 65.7
Autosomal recessive congenital ichthyosis. (a) Congenital ichthyosiform erythroderma. (b) Lamellar ichthyosis. (Courtesy of the Department of Dermato...
Figure 65.11
Clinical phenotype of CERS3 deficiency. Mild plantar keratoderma with hyperlinearity. (Courtesy of the Department of Dermatology, University Hospit...
Figure 65.15
Epidermolytic ichthyosis without mosaicism. (a) Arms, (b) legs, (c) palms indicative of KRT1 and (d) palms indicative of KRT10 mutations. (a)–(c) ...
Figure 65.19
Ichthyosis.Hystrix with striate lesions on the hand. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Figure 65.23
Exfoliative ichthyosis with pronounced plantar keratoderma. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, Germany...
Figure 65.27
Comèl–Netherton syndrome. (a) Trichorrexis invaginata. (b) Congenital ichthyosiform erythroderma with failure to thrive. (c) Ichthyosis linearis circu...
Figure 65.31
Keratitis–ichthyosis–deafness syndrome. Adult with squamous cell carcinoma on the arm. (Courtesy of Dr D. J. Atherton, Great Ormond Street Hospital f...
Figure 65.35
Diagnostic management and clinical monitoring in ichthyosis. ENT, ear, nose and throat; GC‐MS, gas chromatography–mass spectrometry; IgE, immunoglobul...
Figure 65.39
Epidermolytic palmoplantar keratoderma caused by a mutation in KRT9 encoding keratin 9.
Figure 65.43
Mal de Meleda. Plantar phenotype without superinfection. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, Germany.)
Figure 65.47
Punctate palmoplantar keratoderma. Small even keratotic papules on the palms (a) and confluent hyperkeratosis on the feet of the same patient (b). (C...
Figure 65.51
Transient aquagenic keratoderma showing whitish maceration of the palmar skin following immersion. (Courtesy of Dr G. Kavanagh, Royal Infirmary of Ed...
Figure 65.55
Huriez syndrome: (a) keratoderma, and (b) atrophic skin over the dorsa of the hand and sclerodactyly. (Courtesy of Dr M. van Steensel, Department of ...
Figure 65.59
Oculocutaneous tyrosinaemia (Richner–Hanhart syndrome) with callosity‐like hyperkeratoses.
Figure 65.63
Oudtshoorn disease: (a) palmar lesions, and (b) truncal lesions.
Figure 65.67
Digitate hyperkeratosis. (Courtesy of Dr F. A. Ive, Dryburn Hospital, Durham, UK.)
Figure 65.4
Ultrastructural diagnosis of harlequin ichthyosis. (a) Abnormal lamellar bodies in ABCA12 deficiency. (b) Morphology of normal lamellar bodies in gran...
Figure 65.8
Self‐improving congenital ichthyosis. (a) Collodion baby at birth. (b) Mild ichthyosis and minimal erythroderma at the age of 21 months. (Courtesy of...
Figure 65.12
Ultrastructure of transglutaminase‐1 deficient skin with typical cholesterol clefts in the stratum corneum. (Courtesy of Dr I. Hausser, Heidelberg, G...
Figure 65.16
Superficial epidermolytic ichthyosis. Involvement around the navel. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster,...
Figure 65.20
Erythrokeratoderma variabilis. Migrating polycyclic erythematous lesions.
Figure 65.24
Conradi–Hünermann–Happle syndrome. (Courtesy of Dr D. J. Atherton, London, UK.)
Figure 65.28
Inflammatory peeling skin disease (peeling skin syndrome type B). (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, G...
Figure 65.32
Neutral lipid storage disease with ichthyosis. (a) Lipid vacuoles (Jordan anomaly). (b) Ichthyosiform erythroderma. Courtesy of Dr M. Judge, Salford ...
Figure 65.36
Acquired ichthyosis in a man with cutaneous T‐cell lymphoma.
Figure 65.40
‘Voerner–Unna–Thost’ keratoderma: even yellow hyperkeratosis of the sole with red border.
Figure 65.44
Mal de Meleda. Trichophyton rubrum superinfection of the left hand. (Courtesy of the Department of Dermatology, University Hospital Münster, Münste...
Figure 65.48
Spiny keratoderma. Present since the age of 20 on the palms and soles. Son and daughter also affected.
Figure 65.52
Aquagenic palmar wrinkling in cystic fibrosis.
Figure 65.56
Tylosis with oesophageal cancer (Howel‐Evans syndrome). (a) Keratoderma and (b) oral mucosal lesions. (Courtesy of Professor W. R. Tyldesley, Liverpo...
Figure 65.60
Keratoderma climactericum.
Figure 65.64
Disseminated superficial actinic porokeratoses: annular keratotic lesions with a raised margin.
Figure 65.68
Flegel disease: polygonal keratotic lesions on the legs.