Ichthyosis vulgaris. (a) Fine scaling and (b) accentuated palmar creases. Courtesy of (a) Dr M. Judge, Salford Royal NHS Trust, UK ; (b) the Departme...
Autosomal recessive congenital ichthyosis. Sheddding of collodion membranes after 1 week.
(a,b) Clinical phenotype of ALOXE3 mutations. Note palmoplantar hyperlinearity resembling accentuated creases in ichthyosis vulgaris (in b). (Court...
Histological diagnosis of epidermolytic hyperkeratosis.
Moulting (‘Mauserung’) phenomenon in superficial epidermolytic ichthyosis. (Courtesy of the Department of Dermatology, University Hospital Münster, M...
Symmetrical progressive erythrokeratoderma. (Courtesy of Dr A. G. Smith, North Staffordshire Hospital, Stoke‐on‐Trent, UK.)
Congenital hemidysplasia–ichthyosiform naevus–limb defect (CHILD) naevus with yellowish keratosis and ipsilateral limb defect. (Courtesy of the Depar...
Keratolysis exfoliativa of the palms.
Trichothiodystrophy. Lamellar scaling similar to bathing suit ichthyosis.
Acquired ichthyosis in an adult Asian man with multisystem sarcoidosis. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Pachyonychia congenita: (a) focal keratoderma on mechanically stressed areas; and (b) typical wedge‐shaped nail.
Marginal papular keratoderma (acrokeratoelastoidosis, punctate palmoplantar keratoderma type 3 (PPKP3)): crateriform punctate keratosis at the margin ...
Vohwinkel syndrome: (a) ‘starfish’ lesions; and (b) pseudo‐ainhum.
Papillon–Lefèvre syndrome: (a) Loss of dentition. (b) Diffuse plantar hyperkeratosis. (c) Psoriasiform palmar phenotype.
Keratoderma associated with lupus erythematosus. (Courtesy of Dr I. Sarkany, Royal Free Hospital, London, UK.)
Porokeratosis of Mibelli.
Circumscribed hypokeratosis on the inner part of the forefoot of a female patient. (Courtesy of Dr F. Schedel, Department of Dermatology, University ...
Recessive X‐linked ichthyosis. (a) Scaling on the arm, (b) on the legs, (c) on the trunk and (d) patient with light grey scaling. Courtesy of (a)–(c)...
Bathing suit ichthyosis. Lamellar scaling on areas with high skin temperature. (Courtesy of the Department of Dermatology, University Hospital Münste...
Clinical phenotype of NIPAL4 mutations. (a,b) Diffuse yellowish keratoderma on palms and soles. (c) Reticulate scaling on the trunk. (Courtesy of t...
Special genetic aspect in keratinopathic ichthyosis. (a) Epidermolytic naevus in a father of an affected boy with generalized epidermolytic ichthyosis...
Congenital reticular ichthyosiform erythroderma. Note pale confetti‐like spots representing localized spontaneous healing. (Courtesy of the Departmen...
Keratosis linearis–ichthyosis congenita–sclerosing keratoderma (KLICK). Note the linear distribution of the keratotic papules.
Ichthyosis follicularis–alopecia–photophobia (IFAP) syndrome. (Courtesy of Dr A. S. Paller, Department of Dermatology and Pediatrics, Chicago, USA.)
Sjögren–Larsson syndrome. A 3‐year‐old girl with spastic diplegia. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Ichthyosis prematurity syndrome. (a) Neonatal presentation. (b) Same patient after 3 months. Note mild velvet‐like skin texture. (Courtesy of the Dep...
Pityriasis rotunda. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
(a) Non‐epidermolytic palmoplantar keratoderma suggestive of AQP5 . (b) Palm of a 38‐year‐old man, who reported on extreme skin sensitivity to water ...
Striate and focal palmoplantar keratoderma. (a) Hands and (b) feet belong to the same patient. (Courtesy of the Department of Dermatology, University...
Cole disease. (a) Forearm with hypopigmentation and (b) mild keratoderma in the same patient. (Courtesy of Dr Y. Gilaberte, Hospital San Jorge, Huesc...
Mitochondrial keratoderma with deafness.
Olmsted syndrome: (a) gross keratoderma with striate features, and (b) periorificial hyperkeratosis. (Courtesy of Professor R. K. Winkelmann, Mayo Cl...
Norwegian scabies manifesting with keratoderma. (Courtesy of Dr. N. Walker, Oxford Radcliffe Hospital, Oxford, UK.)
Kyrle disease/acquired perforating dermatosis: large keratinous plugs on the thigh.
Harlequin ichthyosis. (a) Neonate, (b) aged 6 weeks on retinoid therapy and (c) 6 months. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Autosomal recessive congenital ichthyosis. (a) Congenital ichthyosiform erythroderma. (b) Lamellar ichthyosis. (Courtesy of the Department of Dermato...
Clinical phenotype of CERS3 deficiency. Mild plantar keratoderma with hyperlinearity. (Courtesy of the Department of Dermatology, University Hospit...
Epidermolytic ichthyosis without mosaicism. (a) Arms, (b) legs, (c) palms indicative of KRT1 and (d) palms indicative of KRT10 mutations. (a)–(c) ...
Ichthyosis.Hystrix with striate lesions on the hand. Courtesy of Dr M. Judge, Salford Royal NHS Trust, UK.
Exfoliative ichthyosis with pronounced plantar keratoderma. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, Germany...
Comèl–Netherton syndrome. (a) Trichorrexis invaginata. (b) Congenital ichthyosiform erythroderma with failure to thrive. (c) Ichthyosis linearis circu...
Keratitis–ichthyosis–deafness syndrome. Adult with squamous cell carcinoma on the arm. (Courtesy of Dr D. J. Atherton, Great Ormond Street Hospital f...
Diagnostic management and clinical monitoring in ichthyosis. ENT, ear, nose and throat; GC‐MS, gas chromatography–mass spectrometry; IgE, immunoglobul...
Epidermolytic palmoplantar keratoderma caused by a mutation in KRT9 encoding keratin 9.
Mal de Meleda. Plantar phenotype without superinfection. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, Germany.)
Punctate palmoplantar keratoderma. Small even keratotic papules on the palms (a) and confluent hyperkeratosis on the feet of the same patient (b). (C...
Transient aquagenic keratoderma showing whitish maceration of the palmar skin following immersion. (Courtesy of Dr G. Kavanagh, Royal Infirmary of Ed...
Huriez syndrome: (a) keratoderma, and (b) atrophic skin over the dorsa of the hand and sclerodactyly. (Courtesy of Dr M. van Steensel, Department of ...
Oculocutaneous tyrosinaemia (Richner–Hanhart syndrome) with callosity‐like hyperkeratoses.
Oudtshoorn disease: (a) palmar lesions, and (b) truncal lesions.
Digitate hyperkeratosis. (Courtesy of Dr F. A. Ive, Dryburn Hospital, Durham, UK.)
Ultrastructural diagnosis of harlequin ichthyosis. (a) Abnormal lamellar bodies in ABCA12 deficiency. (b) Morphology of normal lamellar bodies in gran...
Self‐improving congenital ichthyosis. (a) Collodion baby at birth. (b) Mild ichthyosis and minimal erythroderma at the age of 21 months. (Courtesy of...
Ultrastructure of transglutaminase‐1 deficient skin with typical cholesterol clefts in the stratum corneum. (Courtesy of Dr I. Hausser, Heidelberg, G...
Superficial epidermolytic ichthyosis. Involvement around the navel. (Courtesy of the Department of Dermatology, University Hospital Münster, Münster,...
Erythrokeratoderma variabilis. Migrating polycyclic erythematous lesions.
Conradi–Hünermann–Happle syndrome. (Courtesy of Dr D. J. Atherton, London, UK.)
Inflammatory peeling skin disease (peeling skin syndrome type B). (Courtesy of the Department of Dermatology, University Hospital Münster, Münster, G...
Neutral lipid storage disease with ichthyosis. (a) Lipid vacuoles (Jordan anomaly). (b) Ichthyosiform erythroderma. Courtesy of Dr M. Judge, Salford ...
Acquired ichthyosis in a man with cutaneous T‐cell lymphoma.
‘Voerner–Unna–Thost’ keratoderma: even yellow hyperkeratosis of the sole with red border.
Mal de Meleda. Trichophyton rubrum superinfection of the left hand. (Courtesy of the Department of Dermatology, University Hospital Münster, Münste...
Spiny keratoderma. Present since the age of 20 on the palms and soles. Son and daughter also affected.
Aquagenic palmar wrinkling in cystic fibrosis.
Tylosis with oesophageal cancer (Howel‐Evans syndrome). (a) Keratoderma and (b) oral mucosal lesions. (Courtesy of Professor W. R. Tyldesley, Liverpo...
Disseminated superficial actinic porokeratoses: annular keratotic lesions with a raised margin.
Flegel disease: polygonal keratotic lesions on the legs.