Melanocytes in culture.
A simplified overview of the major metabolic pathways in the synthesis of melanins and trichochromes. (From Prota 1988 [ ], with permission from the c...
Melasma in an adult male from the Indian subcontinent.
(a,b) Freckles in an 11‐year‐old boy.
Generalized pigmentation in a woman aged 33 years with systemic sclerosis.
Vitamin B 12 deficiency: (a) generalized mottled hypermelanosis as presenting feature of pernicious anaemia in a 16‐year‐old boy with a 4‐year histor...
Minocycline pigmentation: marked dyspigmentation of the lower legs resulting from minocycline therapy commenced 2 years earlier as adjunctive therapy ...
Phytophotodermatitis: acute irregular blisters across the palms after grasping giant hogweed.
Algorithm for the differential diagnosis of hypomelanosis.
(a,b) Typical distribution of vitiligo on dorsum of the hand seen under Wood's light.
Hypochromic vitiligo affecting the back. (From Ezzedine et al . 2015 [ ] reproduced with permission from the copyright holder Wiley.)
Halo naevi in different stages of evolution concurrently in a 13‐year‐old girl: (a) early depigmentation; (b) established halo naevus; (c) faint pink ...
Progressive macular hypomelanosis in an 18‐year‐old man. (Reproduced with permission from the copyright holder Springer Publishing Company, from Rely...
Haemosiderin staining on the shins of a 41‐year‐old rugby football player resulting from repeated minor trauma.
Keloid reaction to decorative tattoo: flattened areas have responded to the injection of triamcinolone.
Voigt–Futcher lines. (Courtesy of the late Dr R. R. M. Harman, Bristol Royal Infirmary, Bristol, UK.)
Structure of trichochrome B, one of six trichochromes so far identified.
(a,b) Poikiloderma of Civatte: showing submental and submandibular sparing on the neck of a 43‐year‐old man.
Eruptive lentiginosis: 4‐month history of widespread eruption of lentigines over the neck, trunk and limbs in a healthy 49‐year‐old female. Note lenti...
Morphoea. Hyperpigmentation was the presenting symptom.
(a,b) Amiodarone pigmentation after 5 years of therapy: note slaty‐blue dyspigmentation of the forehead, nose, cheeks and earlobe.
(a,b) Pigmented fixed drug eruption: extensive eruption following repeated courses of tetracycline.
Post‐inflammatory hypermelanosis on the back following propranolol‐provoked lichenoid drug reaction.
Vitiligo. Epidermal sheet of marginal depigmented area showing marked reduction in the number of melanocytes.
Segmental vitiligo on the trunk seen under Wood's light. Note regressing congenital naevus in the centre of the affected area.
(a,b) Vitiligo: before and after camouflage of the hands.
Hypopigmentation in a girl with resolving psoriasis.
Depigmentation on the face following treatment of melasma with monobenzylether of hydroquinone. (Courtesy of St John's Dermatology Centre, London, UK...
Haemosiderosis of the gaiter area in a 98‐year‐old man with longstanding venous insufficiency: note atrophie blanche above the medial malleolus.
Chrysiasis: mild lilac discoloration on the forehead and eyelids contrasting with the yellow of the elastotic skin on the bridge of the nose and eyebr...
Regional variation in the distribution of epidermal melanocytes. The figures are mean values per mm 2 ± standard error of the mean. (From Rosdahl & R...
Diffuse hyperpigmentation with darkening of the hair and mucous membranes in a woman with Nelson syndrome following bilateral adrenalectomy.
Erythromelanosis follicularis of the face and neck. (By permission of the copyright holder John Wiley and Sons, from Ermertcan et al . Erythromelanos...
Addison disease: diffuse hypermelanosis of the skin (a) and gingivae (b) in a 13‐year‐old girl and of the labial mucosa (c) and tongue (d) of a 15‐yea...
(a,b) Haemochromatosis: a 74‐year‐old male with gradual increase in skin pigmentation for 5 years. Extensive stippled skin pigmentation becoming confl...
(a–c) Chloroquine pigmentation: patient received chloroquine for 9 years for rheumatoid arthritis and had developed increasing pigmentation of the per...
Phytophotodermatitis. Linear, streaky pigmentation following an acute blistering reaction caused by giant hogweed and sunlight.
Notalgia paraesthetica: note the circumscribed area of hypermelanosis near the base of the left scapula.
[Isomorphic or Koebner phenomenon at site of a scratch in a patient with vitiligo.
(a,b) Extensive vitiligo in a South Asian man: view of the sides of the face showing the convex expanding margins of the vitiliginous skin ‘eating int...
(a,b) Segmental vitiligo (a) before and (b) after treatment with non‐cultured epidermal cell transplantation.
Occupational vitiligo due to tertiary‐butylphenol.
Haemosiderosis secondary to capillaritis which first erupted 6 months previously in a 57‐year‐old male.
(a–d) Traumatic tattoo: accidental tattoo following explosion during school chemistry experiment; excellent response to Nd : YAG laser.
Melanocyte in the basal layer of the epidermis.
(a,b) Melasma in two female patients.
Peribuccal pigmentation of Brocq. (Courtesy and with permission of Dr Luciano Schiazza, Genoa, Italy.)
Nelson syndrome: hypermelanosis of the dorsa of the hands and of the palmar creases.
Macular amyloidosis: typical rippled hypermelanosis on the upper back of a 40‐year‐old Indian woman.
Chlorpromazine pigmentation: patchy bands of muddy pigmentation extending across the nose to the paranasal and preauricular skin in an elderly male re...
Ashy dermatosis: views of two females aged 31 years (a,b) and 15 years (c) with multiple muddy grey non‐inflamed macules on the skin. (From Chang et ...
Typical distribution of vitiligo on the wrist and volar surface of the hand seen under Wood's light.
(a) Multiple halo naevi in a young man who also had vitiligo. (b) Unusually large halo naevus. (c) Halo phenomenon developing within a malignant melan...
Hypomelanotic macules on a sun‐exposed arm compared with tan‐coloured macules on the trunk of the sun‐protected abdominal skin of a woman with pityria...
Typical appearances on the shins of a 57‐year‐old Afro‐Caribbean woman (a) with close‐up view illustrating discrete guttate hypomelanotic macules (b)....
Carotenoderma: note yellowish hue of the palm on the right compared with the normal palm on the left. (Reproduced with permission and courtesy of the...
Lichenoid reaction in the red areas of a tattoo.