Part 1, Reference for Chapter 10: Cutaneous Response to Injury and Wound Healing
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Introduction
- 1 Wound healing: a paradigm for regeneration. Mayo Clin Proc 2013;88:1022–31. Cross Ref link Pubmed link , , .
- 2 Oxygen and the regulation of gene expression in wounds. Wound Repair Regen 2003;11:445–51. Cross Ref link Pubmed link , .
- 3 The role of hypoxia‐inducible factor in wound healing. Adv Wound Care (New Rochelle) 2014;3:390–9. Cross Ref link Pubmed link , , , et al.
- 4 Nitric oxide restores impaired healing in normoglycaemic diabetic rats. J Wound Care 2007;16:311–16. Cross Ref link Pubmed link , , , et al.
- 5 Leptin is an autocrine/paracrine regulator of wound healing. FASEB J 2003;17:1895–7. Pubmed link , , , et al.
- 6 Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003;83:835–70. Pubmed link , .
- 7 The roles of receptor tyrosine kinases and their ligands in the wound repair process. Semin Cell Dev Biol 2012;23:963–70. Cross Ref link Pubmed link , , .
- 8 Estrogen promotes cutaneous wound healing via estrogen receptor beta independent of its antiinflammatory activities. J Exp Med 2010;207:1825–33. Cross Ref link Pubmed link , , , et al.
- 9 The hormonal regulation of cutaneous wound healing. Clin Dermatol 2007;25:56–62. Cross Ref link Pubmed link , , .
- 10 Androgens modulate the inflammatory response during acute wound healing. J Cell Sci 2006;119:722–32. Cross Ref link Pubmed link , , , et al.
- 11 Androgen receptor‐mediated inhibition of cutaneous wound healing. J Clin Invest 2002;110:615–24. Cross Ref link Pubmed link , .
- 12 Opioids heal ischemic wounds in the rat. Wound Repair Regen 2005;13:165–74. Cross Ref link Pubmed link , , , .
- 13 Up‐regulation of elastase in acute wounds of healthy aged humans and chronic venous leg ulcers are associated with matrix degradation. Lab Invest 1997;77:281–8. Pubmed link , , , et al.
- 14 Collagenase‐2 (MMP‐8) and matrilysin‐2 (MMP‐26) expression in human wounds of different etiologies. Wound Repair Regen 2007;15:47–57. Cross Ref link Pubmed link , , , et al.
- 15 Differential expression of tissue inhibitors of metalloproteinases (TIMP‐1, ‐2, ‐3, and ‐4) in normal and aberrant wound healing. Hum Pathol 1999;30:795–802. Cross Ref link Pubmed link , , .
- 16 ‘See‐saw’ expression of microRNA‐198 and FSTL1 from a single transcript in wound healing. Nature 2013;495:103–6. Cross Ref link Pubmed link , , , et al.
- 17 The histology of diabetic ulcers. Diabet Med 1996;13:530–3. , , , et al.
- 18 Early fetal healing as a model for adult organ regeneration. Tissue Eng 2007;13:1789–98. Cross Ref link Pubmed link , , .
- 19 Aging and wound healing. World J Surg 2004;28:321–6. Cross Ref link Pubmed link , .
- 20 Perceived stress and cortisol levels predict speed of wound healing in healthy male adults. Psychoneuroendocrinol 2004;29:798–809. Cross Ref link , , , et al.
Inflammation and the immune response
- 21 Molecular mechanisms of VEGF‐A action during tissue repair. J Investig Dermatol Symp Proc 2006;11:79–86. Cross Ref link Pubmed link , .
- 22 Inflammation in wound repair: molecular and cellular mechanisms. J Invest Dermatol 2007;127:514–25. Cross Ref link Pubmed link , , .
- 23 Absence of IL‐1 receptor antagonist impaired wound healing along with aberrant NF‐kappaB activation and a reciprocal suppression of TGF‐beta signal pathway. J Immunol 2006;176:5598–606. Cross Ref link Pubmed link , , , , .
- 24 Catecholamine stress alters neutrophil trafficking and impairs wound healing byβ2‐adrenergic receptor‐mediated upregulation of IL‐6. J Invest Dermatol 2014;134:809–17. Cross Ref link Pubmed link , , , et al.
- 25 Role of endothelial selectins in wound repair. Am J Pathol 1997;150:1701–9. Pubmed link , , , et al.
- 26 The effect of thrombocytopenia on dermal wound healing. J Invest Dermatol 2003;120:1130–7. Cross Ref link Pubmed link , , , .
- 27 Wound‐healing defect of CD18(–/–) mice due to a decrease in TGF‐beta1 and myofibroblast differentiation. EMBO J 2005;24:3400–10. Cross Ref link Pubmed link , , , et al.
- 28 The role of the macrophage in wound repair. Am J Pathol 1975;78:71–100. Pubmed link , .
- 29 Role of TGF beta‐mediated inflammation in cutaneous wound healing. J Investig Dermatol Symp Proc 2006;11:112–17. Cross Ref link Pubmed link , , , et al.
- 30 Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan. J Cell Biol 2003;162:49–60. Cross Ref link , , , et al.
- 31 Chemokines in cutaneous wound healing. J Leukoc Biol 2001;69:513–21. Pubmed link , .
- 32 Understanding the role of immune regulation in wound healing. Am J Surg 2004;187:S11–6. Cross Ref link , .
- 33 IL‐33 accelerates cutaneous wound healing involved in upregulation of alternatively activated macrophages. Mol Immunol 2013;56:347–53. Cross Ref link Pubmed link , , , et al.
- 34 Dendritic epidermal T cells regulate skin homeostasis through local production of insulin‐like growth factor 1. Nat Immunol 2005;6:73–9. Cross Ref link Pubmed link , , , et al.
- 35 Fgf9 from dermal γδT cells induces hair follicle neogenesis after wounding. Nat Med 2013;19:916–23. Cross Ref link Pubmed link , , , et al.
- 36 Gammadelta T cell‐induced hyaluronan production by epithelial cells regulates inflammation. J Exp Med 2005;201:1269–79. Cross Ref link Pubmed link , , , et al.
- 37 During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med 1996;2:992–7. Cross Ref link Pubmed link , , , et al.
- 38 IL‐6 modulates alpha‐smooth muscle actin expression in dermal fibroblasts from IL‐6‐deficient mice. J Invest Dermatol 2006;126:561–8. Cross Ref link Pubmed link , , .
- 39 Wound healing in the PU.1 null mouse‐tissue repair is not dependent on inflammatory cells. Curr Biol 2003;13:1122–8. Cross Ref link Pubmed link , , , et al.
- 40 Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound. Mol Cell Biol 2002;22:5492–505. Cross Ref link Pubmed link , , , et al.
- 41 Toll‐like receptor 4 has an essential role in early skin wound healing. J Invest Dermatol 2013;133:258–67. Cross Ref link Pubmed link , , , .
Re‐epithelialization
- 42 A wound‐induced keratin inhibits Src activity during keratinocyte migration and tissue repair. J Cell Biol 2012;197:381–9. Cross Ref link Pubmed link , .
- 43 Interferon‐inducible protein 9 (CXCL11)‐induced cell motility in keratinocytes requires calcium flux‐dependent activation of mu‐calpain. Mol Cell Biol 2005;25:1922–41. Cross Ref link Pubmed link , , , .
- 44 Epidermal growth factor and transforming growth factor‐α specifically induce the activation‐ and hyperproliferation‐associated keratins 6 and 16. Proc Natl Acad Sci USA 1993;90:6786–9. Cross Ref link Pubmed link , , , et al.
- 45 FOXO1 promotes wound healing through the up‐regulation of TGF‐β1 and prevention of oxidative stress. J Cell Biol 2013;203:327–43. Cross Ref link Pubmed link , , , , , .
- 46 c‐Met is essential for wound healing in the skin. J Cell Biol 2007;177:151–62. Cross Ref link Pubmed link , , , et al.
- 47 Impaired epidermal wound healing in vivo upon inhibition or deletion of Rac1. J Cell Sci 2007;120:1480–90. Cross Ref link Pubmed link , , , et al.
- 48 Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2. Nat Commun 2014;5:4088. Pubmed link , , , et al.
- 49 The p38‐MAPK/SAPK pathway is required for human keratinocyte migration on dermal collagen. J Invest Dermatol 2001;117:1601–11. Cross Ref link Pubmed link , , , et al.
- 50 Keratinocyte specific ablation of Stat3 exhibits impaired skin remodelling but does not affect skin morphogenesis. EMBO J 1999;18:4657–68. Cross Ref link Pubmed link , , , et al.
- 51 Transcription factor activation in response to cutaneous injury: role of AP‐1 in re‐epithelialization. Wound Repair Regen 2002;10:5–15. Cross Ref link Pubmed link , .
- 52 Anti‐apoptotic role of PPARβ in keratinocytes via transcriptional control of the Akt1 pathway. Mol Cell 2002;10:721–33. Cross Ref link Pubmed link , , , et al.
- 53 Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplification. J Cell Sci 2005;118:1693–704. Cross Ref link Pubmed link , , , et al.
- 54 Interaction of epidermal growth factor, Ca2+, and matrix metalloproteinase‐9 in primary keratinocyte migration. Wound Repair Regen 2007;15:907–15. Cross Ref link Pubmed link , .
- 55 Differential expression of urokinase‐type plasminogen activator and its type‐1 inhibitor during healing of mouse skin wounds. J Invest Dermatol 1991;97:803–11. Cross Ref link Pubmed link , , , et al.
- 56 Hypoxia induces epidermal keratinocyte matrix metalloproteinase‐9 secretion via the protein kinase C pathway. J Cell Physiol 2008;214:47–55. Cross Ref link Pubmed link , , , .
- 57 Increased migration of murine keratinocytes under hypoxia is mediated by induction of urokinase plasminogen activator. J Invest Dermatol 2002;119:1304–9. Cross Ref link Pubmed link , .
- 58 Impaired wound healing in mice with a disrupted plasminogen gene. Nat Med 1996;2:287–92. Cross Ref link Pubmed link , , , et al.
- 59 Ectopic expression of syndecan‐1 in basal epidermis affects keratinocyte proliferation and wound re‐epithelialization. J Invest Dermatol 2008;128:26–34. Cross Ref link Pubmed link , , , et al.
- 60 Fibronectin matrix deposition and fibronectin receptor expression in healing and normal skin. J Invest Dermatol 1990;94:128–34. Cross Ref link .
- 61 TGF‐β1 stimulates expression of keratinocyte integrins during re‐epithelialization of cutaneous wounds. J Invest Dermatol 1994;103:221–7. Cross Ref link Pubmed link , , .
- 62 Re‐epithelialization of normal excisional wounds is associated with a switch from αVβ5 to αVβ6 integrins. Br J Dermatol 1996;13:46–51. Cross Ref link , , , et al.
- 63 Fibrinogen and fibrin are anti‐adhesive for keratinocytes: a mechanism for fibrin eschar slough during wound repair. J Invest Dermatol 2001;117:1369–81. Cross Ref link Pubmed link , , , et al.
- 64 Transforming growth factor‐alpha: a major human serum factor that promotes human keratinocyte migration. J Invest Dermatol 2006;126:2096–105. Cross Ref link Pubmed link , , , , .
- 65 A ‘traffic control’ role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol 2006;172:1093–105. Cross Ref link Pubmed link , , , et al.
- 66 Heparin‐binding EGF‐like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci 2005;118:2363–70. Cross Ref link Pubmed link , , , et al.
- 67 Interferon regulatory factor 6 regulates keratinocyte migration. J Cell Sci 2014;127:2840–8. Cross Ref link Pubmed link , , , et al.
- 68 Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. J Biol Chem 2003;278:49495–504. Cross Ref link Pubmed link , , , et al.
- 69 Antimicrobial peptides human beta‐defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines. J Invest Dermatol 2007;127:594–604. Cross Ref link Pubmed link , , , et al.
- 70 Transforming growth factor alpha (TGFalpha)‐stimulated secretion of HSP90alpha: using the receptor LRP‐1/CD91 to promote human skin cell migration against a TGFbeta‐rich environment during wound healing. Mol Cell Biol 2008;28:3344–58. Cross Ref link Pubmed link , , , et al.
- 71 Large induction of keratinocyte growth factor expression in the dermis during wound healing. Proc Natl Acad Sci USA 1992;89:6896–900. Cross Ref link Pubmed link , , , et al.
- 72 Migration of human keratinocytes in plasma and serum and wound re‐epithelialization. Lancet 2003;361:574–6. Cross Ref link Pubmed link , , , et al.
- 73 Collagen VII plays a dual role in wound healing. J Clin Invest 2013;123:3498–509. Cross Ref link Pubmed link , , , , , .
- 74 Initiation of skin basement membrane formation at the epidermo‐dermal interface involves assembly of laminins through binding to cell membrane receptors. J Cell Sci 1998;111:1929–40. Pubmed link , , , et al.
- 75 The generation of anchoring fibrils by epidermal keratinocytes: a quantitative long‐term study. Epithelial Cell Biol 1995;4:93–103. Pubmed link , , , et al.
- 76 Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res 2013;351:255–68. Cross Ref link Pubmed link , , .
- 77 PAI‐1: an integrator of cell signaling and migration. Int J Cell Biol 2011;2011:article ID 562481, doi:10.1155/2011/562481. Cross Ref link Pubmed link , , , et al.
Angiogenesis
- 78 C1q as a unique player in angiogenesis with therapeutic implication in wound healing. Proc Natl Acad Sci USA 2014;111:4209–14. Cross Ref link Pubmed link , , , et al.
- 79 Impact of fibroblast growth factor‐binding protein‐1 expression on angiogenesis and wound healing. Am J Pathol 2011;179:2220–32. Cross Ref link Pubmed link , , , et al.
- 80 Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J Dermatol Sci 2013;72:206–17. Cross Ref link Pubmed link , , , .
- 81 Neuropilin‐1 participates in wound angiogenesis. Am J Pathol 2002;160:289–96. Cross Ref link Pubmed link , , , .
- 82 Transcriptome‐wide analysis of blood vessels laser captured from human skin and chronic wound‐edge tissue. Proc Natl Acad Sci USA 2007;104:14472–7. Cross Ref link Pubmed link , , , et al.
- 83 Transcriptional control of wound repair. Annu Rev Cell Dev Biol 2007;23:69–92. Cross Ref link Pubmed link , .
- 84 Oxidant‐induced vascular endothelial growth factor expression in human keratinocytes and cutaneous wound healing. J Biol Chem 2002;277:33284–90. Cross Ref link Pubmed link , , , et al.
- 85 VEGF‐induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 2006;124:175–89. Cross Ref link Pubmed link , , , et al.
- 86 Overexpression of laminin 8 in human dermal microvascular cells promotes angiogenesis‐related functions. J Invest Dermatol 2006;126:432–40. Cross Ref link Pubmed link , , , et al.
- 87 Fibrin and collagen differentially regulate human dermal microvascular endothelial cell integrins: stabilization of alphaV/beta3 mRNA by fibrin 1. J Invest Dermatol 1999;113:913–19. Cross Ref link Pubmed link , , , et al.
- 88 Human dermal microvascular endothelial cells produce matrix metalloproteinases in response to angiogenic factors and migration. J Invest Dermatol 1995;105:170–6. Cross Ref link Pubmed link , , , et al.
- 89 The ephrins and Eph receptors in angiogenesis. Cytokine Growth Factor Rev 2002;13:75–85. Cross Ref link Pubmed link , , .
- 90 A role for pericytes as microenvironmental regulators of human skin tissue regeneration. J Clin Invest 2009;119:2795–806. Pubmed link , , , et al.
- 91 Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl‐2 and A1 in vascular endothelial cells. J Biol Chem 1998;273:13313–16. Cross Ref link Pubmed link , , .
Fibroblast recruitment, matrix synthesis and scarring
- 92 Intradermal adipocytes mediate fibroblast recruitment during skin wound healing. Development 2013;140:1517–27 Cross Ref link Pubmed link , .
- 93 Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature 2013;504:277–81. Cross Ref link Pubmed link , , , et al.
- 94 Fibroblast migration on fibronectin requires three distinct functional domains. J Invest Dermatol 2003;121:695–705. Cross Ref link Pubmed link , , , et al.
- 95 Keratinocyte–fibroblast interactions in wound healing. J Inv Dermatol 2007;127:998–1008. Cross Ref link , , .
- 96 The roles of receptor tyrosine kinases and their ligands in the wound repair process. Semin Cell Dev Biol 2012;23:963–70. Cross Ref link Pubmed link , , .
- 97 Mechanism of human dermal fibroblast migration driven by type I collagen and platelet‐derived growth factor‐BB. Mol Biol Cell 2004;15:294–309. Cross Ref link Pubmed link , , , et al.
- 98 Formation and function of the myofibroblast during tissue repair. J Invest Dermatol 2007;127:526–37. Cross Ref link Pubmed link .
- 99 Factor Xa stimulates proinflammatory and profibrotic responses in fibroblasts via protease‐activated receptor‐2 activation. Am J Pathol 2008;172:309–20. Cross Ref link Pubmed link , , , et al.
- 100 Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol 2003;149:464–70. Cross Ref link Pubmed link , , , et al.
- 101 Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res 2013;351:255–68. Cross Ref link Pubmed link , , .
- 102 Metalloproteinase activation cascade after burn injury: a longitudinal analysis of the human wound environment. J Invest Dermatol 1994;103:660–4. Cross Ref link Pubmed link , .
- 103 Interleukin‐6 (IL‐6) modulates migration and matrix metalloproteinase function in dermal fibroblasts from IL‐6KO mice. Br J Dermatol 2007;156:1163–71. Cross Ref link Pubmed link , .
- 104 Regenerative wound healing: the role of interleukin‐10. Adv Wound Care (New Rochelle) 2014;3:315–23. Cross Ref link Pubmed link , , , , .
- 105 Effects of basic fibroblast growth factor on the expression of extracellular matrix and matrix metalloproteinase‐1 in wound healing. Clin Exp Dermatol 2008;33:176–82. Cross Ref link Pubmed link , , , et al.
- 106 Skin scarring. BMJ 2003;326:88–92. Cross Ref link Pubmed link , , .
- 107 Age‐related changes in the temporal and spatial distributions of fibrillin and elastin mRNAs and proteins in acute cutaneous wounds of healthy humans. J Pathol 1997;183:80–9. Cross Ref link Pubmed link , , , .
- 108 Induction of hair growth in ear wounds by cultured dermal papilla cells. J Invest Dermatol 1993;101:584–90. Cross Ref link Pubmed link , , .
- 109 Wnt‐dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 2007;447:316–20. Cross Ref link Pubmed link , , , et al.
- 110 Increased expression of β6‐integrin in skin leads to spontaneous development of chronic wounds. Am J Pathol 2004;164:229–42. Cross Ref link Pubmed link , , , et al.
- 111 Fibroblasts from non‐healing human chronic wounds show decreased expression of beta ig‐h3, a TGF‐beta inducible protein. J Dermatol Sci 2008;50:15–23. Cross Ref link Pubmed link , , , et al.
- 112 Expression of TGF‐β and its receptors in murine fetal and adult dermal wounds. Eur J Dermatol 2001;11:424–31. Pubmed link , , , .
- 113 A new quantitative scale for clinical scar assessment. Plast Reconstr Surg 1998;102:1954–61. Cross Ref link Pubmed link , , , et al.
- 114 Scar redness in humans: how long does it persist after incisional and excisional wounding? Plast Reconstr Surg 2008;121:487–96. Cross Ref link Pubmed link , , , et al.
- 115 Neutralizing antibody to TGF‐β1,2 reduces scarring in adult rodents. J Cell Sci 1994;107:1137–57. Pubmed link , , .
- 116 Neutralization of TGF‐β1 and TGF‐β2 or exogenous addition of TGF‐β3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995;108:985–1002. Pubmed link , , .
- 117 Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure. Proc Natl Acad Sci USA 2006;103:9250–5. Cross Ref link Pubmed link , , , et al.
- 118 Dynamics of transforming growth factor beta signaling in wound healing and scarring. Adv Wound Care (New Rochelle) 2013;2:195–214. Cross Ref link Pubmed link , , , .
- 119 Acute downregulation of connexin43 at wound sites leads to a reduced inflammatory response, enhanced keratinocyte proliferation and wound fibroblast migration. J Cell Sci 2006;119:5193–203. Cross Ref link Pubmed link , , , et al.
- 120 Limiting burn extension by transient inhibition of Connexin43 expression at the site of injury. Br J Plast Surg 2005;58:658–67. Cross Ref link Pubmed link , , , et al.
- 121 A connexin43 mimetic peptide promotes regenerative healing and improves mechanical properties in skin and heart. Adv Wound Care (New Rochelle) 2013;2:55–62. Cross Ref link Pubmed link , , , , .
- 122 Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing. J Dermatol Sci 2013;72:206–17. Cross Ref link Pubmed link , , , .
Abnormal wound healing and scarring
- 123 Detection of undegraded fibrin and tumour necrosis factor‐α in venous leg ulcers. J Am Acad Dermatol 1991;25:623–7. Cross Ref link Pubmed link , , , .
- 124 Growth factors and chronic wounds: the need to understand the microenvironment. J Dermatol 1992;19:667–72. Cross Ref link Pubmed link .
- 125 Deletion of a tumor necrosis superfamily gene in mice leads to impaired healing that mimics chronic wounds in humans. Wound Repair Regen 2012;20:353–66. Cross Ref link Pubmed link , , , et al.
- 126 Macrophages – sensors and effectors coordinating skin damage and repair. J Dtsch Dermatol Ges 2014;12(3):214–21. Pubmed link , .
- 127 Inhibition of cell proliferation by chronic wound fluid. Wound Repair Regen 1993;1:181–6. Cross Ref link Pubmed link , , .
- 128 Time‐ and dose‐dependent effects of chronic wound fluid on human adult dermal fibroblasts. Dermatol Surg 2008;34:347–56. Pubmed link , , , et al.
- 129 Chronic wound fluid suppresses proliferation of dermal fibroblasts through a Ras‐mediated signaling pathway. J Invest Dermatol 2005;124:466–74. Cross Ref link Pubmed link , , , et al.
- 130 Mitogen‐activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts. Vasc Endovascular Surg 2006;40:59–66. Cross Ref link , , , .
- 131 Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J Am Acad Dermatol 1991;25:1054–8. Cross Ref link Pubmed link , , , et al.
- 132 Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds. J Proteome Res 2010;9:4758–66. Cross Ref link Pubmed link , , , et al.
- 133 Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res 2013;351:255–68. Cross Ref link Pubmed link , , .
- 134 Patterns of matrix metalloproteinase and TIMP expression in chronic ulcers. Arch Dermatol Res 1998;290(Suppl.): S47–54. Cross Ref link Pubmed link .
- 135 Increased inflammation delays wound healing in mice deficient in collagenase‐2 (MMP‐8). FASEB J 2007;21:2580–91. Cross Ref link Pubmed link , , , et al.
- 136 Extracellular matrix and keratinocyte migration. Clin Exp Dermatol 2001;26:525–30. Cross Ref link Pubmed link .
- 137 Interaction of the microbiome with the innate immune response in chronic wounds. Adv Exp Med Biol 2012;946:55–68. Cross Ref link Pubmed link , .
- 138 Pathogenesis and treatment of impaired wound healing in diabetes mellitus: new insights. Adv Ther 2014;31:817–36. Cross Ref link Pubmed link , , .
- 139 Detection of galectin‐3 and localization of advanced glycation end products (AGE) in human chronic skin wounds. Histol Histopathol 2014;29:251–8. Pubmed link , , , .
- 140 Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients. Proteomics 2013;13:2670–81. Cross Ref link Pubmed link , , , , , .
- 141 Diabetes induces stable intrinsic changes to myeloid cells that contribute to chronic inflammation during wound healing in mice. Dis Model Mech 2013;6:1434–47. Cross Ref link Pubmed link , , , , , .
- 142 Dysfunction of endothelial progenitor cells under diabetic conditions and its underlying mechanisms. Arch Pharm Res 2012;35:223–34. Cross Ref link Pubmed link , , , et al.
- 143 Deletion of neuropeptide Y (NPY) 2 receptor in mice results in blockage of NPY‐induced angiogenesis and delayed wound healing. Proc Natl Acad Sci USA 2003;100:6033–8. Cross Ref link Pubmed link , , , et al.
- 144 A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice. J Clin Invest 2011;121:4348–61. Cross Ref link Pubmed link , , , et al.
- 145 Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol 2004;122:1126–32. Cross Ref link Pubmed link , , , et al.
- 146 A genome‐wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet 2010;42:768–71. Cross Ref link Pubmed link , , , et al.
- 147 Growth kinetics and collagen synthesis of normal skin, normal scar and keloid fibroblasts in vitro. J Cell Physiol 1979;98:341–6. Cross Ref link Pubmed link , , .
- 148 Cell size and growth characteristics of cultured fibroblasts isolated from normal and keloid tissue. Plast Reconstr Surg 1976;57:207–12. Cross Ref link Pubmed link , .
- 149 Alterations in fibroblast α1β1 integrin collagen receptor expression in keloids and hypertrophic scars. J Invest Dermatol 2002;118:409–15. Cross Ref link Pubmed link , , , et al.
- 150 Detection of apoptosis in keloids and a comparative study on apoptosis between keloids, hypertrophic scars, normal healed flat scars, and dermatofibroma. Wound Repair Regen 2001;9:501–6. Cross Ref link Pubmed link , , , et al.
- 151 Fibroblasts cocultured with keloid keratinocytes: normal fibroblasts secrete collagen in a keloid‐like manner. Am J Physiol Cell Physiol 2002;283:C212–22. Cross Ref link Pubmed link , , , et al.
- 152 Keloid‐derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound Repair Regen 2013;21:530–44. Cross Ref link Pubmed link , , , , , .
- 153 Site‐specific immunophenotyping of keloid disease demonstrates immune upregulation and the presence of lymphoid aggregates. Br J Dermatol 2012;167:1053–66. Cross Ref link Pubmed link , , , , , .
Age‐related changes in wound healing
- 154 Wound healing: aiming for perfect skin regeneration. Science 1997;276:75–81. Cross Ref link Pubmed link .
- 155 Scar formation: the spectral nature of fetal and adult wound repair. Plast Reconstr Surg 1996;97:854–60. Cross Ref link Pubmed link , , , et al.
- 156 Fetal wound healing biomarkers. Dis Markers 2013;35:939–44. Cross Ref link Pubmed link , , , , , .
- 157 Mast cells contribute to scar formation during fetal wound healing. J Invest Dermatol 2012;132:458–65. Cross Ref link Pubmed link , , , , , .
- 158 Immunohistochemical localization of growth factors in fetal wound healing. Dev Biol 1991;147:207–15. Cross Ref link Pubmed link , .
- 159 Control of scarring in adult wounds by neutralizing antibodies to transforming growth factor‐β (TGF‐β). Lancet 1992;339:213–14. Cross Ref link Pubmed link , , .
- 160 Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell 2013;155:778–92. Cross Ref link Pubmed link , , , et al.
- 161 The effect of ageing on cutaneous wound healing. J Anat 1995;187:1–26. Pubmed link , , .
- 162 Aging‐dependent reduction in glyoxalase 1 delays wound healing. Gerontology 2013;59:427–37. Cross Ref link Pubmed link , , , et al.
- 163 Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol 2013;190:1746–5. Cross Ref link Pubmed link , , , , .
- 164 Human ageing impairs injury induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)‐1 and ‐2 proteins and mRNA. J Pathol 1997;183:169–76. Cross Ref link Pubmed link , , , et al.
- 165 The role of estrogen deficiency in skin ageing and wound healing. Biogerontology 2012;13:3–20. Cross Ref link Pubmed link , .
- 166 Androgens influence expression of matrix proteins and proteolytic factors during cutaneous wound healing. Lab Invest 2007;87:871–81. Cross Ref link Pubmed link , , , .
- 167 Estrogen accelerates cutaneous wound healing associated with an increase in TGF‐β1 levels. Nat Med 1997;3:1209–15. Cross Ref link Pubmed link , , , et al.
- 168 Selective estrogen receptor modulators accelerate cutaneous wound healing in ovariectomized female mice. Endocrinology 2008;149:551–7. Cross Ref link Pubmed link , , , .
- 169 MicroRNA‐7 inhibition rescues age‐associated loss of epidermal growth factor receptor and hyaluronan‐dependent differentiation in fibroblasts. Aging Cell 2014;13:235–44. Cross Ref link Pubmed link , , , .
Physiological basis of the treatment of wounds
- 170 Practical applications of experimental studies in the care of the primarily closed wound. Am J Surg 1982;104:273–82. Cross Ref link , .
- 171 Distinct fibroblast lineages determine dermal architecture in skin development and repair. Nature 2013;504:277–81. Cross Ref link Pubmed link , , , et al.
- 172 Accelerated epithelialization under a highly water vapour permeable wound dressing is associated with increased precipitation of fibrin (ogen) and fibronectin. J Invest Dermatol 1990;94:477–84. Cross Ref link Pubmed link , , .
Novel therapies for wound healing
Growth factors to augment wound healing
- 173 Biologic enhancement of wound healing. Clin Plast Surg 2007;34:659–71. Cross Ref link Pubmed link , .
- 174 The role of topical growth factors in chronic wounds. Curr Drug Deliv 2007;4:195–204. Cross Ref link Pubmed link , , .
- 175 The role of fibroblasts in tissue engineering and regeneration. Br J Dermatol 2007;156:1149–55. Cross Ref link Pubmed link , , .
- 176 Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Repair Regen 1999;7:442–52. Cross Ref link Pubmed link , , , et al.
- 177 Generation of a chimeric plasmin‐resistant VEGF165/VEGF183 (132‐158) protein and its comparative activity. Protein Pept Lett 2013;20:947–54. Cross Ref link Pubmed link , , , , , .
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