Antiphospholipid syndrome

Mark Goodfield, Shyamal Wahie


The antiphospholipid syndrome is a well‐described clinical scenario characterized by the occurrence of thrombotic disease affecting all parts of the vascular system, with symptoms that vary with the area involved. It is caused by the presence of functional antiphospholipid antibodies targeting elements of the coagulation system. It may occur alone, or in combination with connective tissue diseases. Therapy following diagnosis in symptomatic individuals consists of anticoagulation.
Keywords thrombosis, lupus anticoagulant, antiphospholipid antibodies, placental insufficiency, Hughes syndrome, pregnancy morbidity


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